ArticleProceedings of the National Academy of Sciences of the United States of America2003
Adaptive mutation: general mutagenesis is not a programmed response to stress but results from rare coamplification of dinB with lac.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 93 citations in OpenAlex.
- Metabolic remodeling of microorganisms by mobile genetic elements alters mutualistic community composition.mSystems · 2025Article
- Efficient mathematical methodology to determine multistep mutant burden in spatially growing cell populations.PNAS nexus · 2025Article
- Review
- Multiple genetic paths including massive gene amplification allowProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Amplicon Remodeling and Genomic Mutations Drive Population Dynamics after Segmental Amplification.Molecular biology and evolution · 2022Article
- A Comprehensive View of Translesion Synthesis in Escherichia coli.Microbiology and molecular biology reviews : MMBR · 2020Review
- Selective Inbreeding: Genetic Crosses Drive Apparent Adaptive Mutation in the Cairns-Foster System ofGenetics · 2020Article
- Selection and Plasmid Transfer Underlie Adaptive Mutation inGenetics · 2018Article
- Selection-Enhanced Mutagenesis ofGenetics · 2018Article
- Large-scale recoding of a bacterial genome by iterative recombineering of synthetic DNA.Nucleic acids research · 2017Article
- λ Recombination and Recombineering.EcoSal Plus · 2016Review
- Mutation--The Engine of Evolution: Studying Mutation and Its Role in the Evolution of Bacteria.Cold Spring Harbor perspectives in biology · 2015Review
- The Origin of Mutants Under Selection: How Natural Selection Mimics Mutagenesis (Adaptive Mutation).Cold Spring Harbor perspectives in biology · 2015Review
- Article
- Polymerase exchange on single DNA molecules reveals processivity clamp control of translesion synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Translesion DNA synthesis and mutagenesis in prokaryotes.Cold Spring Harbor perspectives in biology · 2013Review
- Stress-Induced Mutagenesis.EcoSal Plus · 2012Article
- Pathways of genetic adaptation: multistep origin of mutants under selection without induced mutagenesis in Salmonella enterica.Genetics · 2012Article
- Article
- Effect of growth under selection on appearance of chromosomal mutations in Salmonella enterica.Genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In a particular genetic system, selection stimulates reversion of a lac mutation and causes genome-wide mutagenesis (adaptive mutation). Selection allows rare plated cells with a duplication of the leaky lac allele to initiate clones within which further lac amplification improves growth rate. Growth and amplification add mutational targets to each clone and thereby increase the likelihood of reversion. We suggest that general mutagenesis occurs only in clones whose lac amplification includes the nearby dinB+ gene (for error-prone DNA polymerase IV). Thus mutagenesis is not a programmed response to stress but a side effect of amplification in a few clones; it is not central to the effect of selection on reversion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.