ArticlePlant molecular biology2003
Cloning and characterization of the durable tomato mosaic virus resistance gene Tm-2(2) from Lycopersicon esculentum.
Article in Plant molecular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed.
- Advances in genomics-driven genetic decoding and genomic design breeding in tomato.Horticulture research · 2026Article
- The durable resistance gene Tm-22 remains partially resistant to tomato brown rugose fruit virus.PLoS pathogens · 2026Article
- Integrated multi-omics analyses elucidate the key regulatory networks in response to Tomato brown rugose fruit virus infection in Solanum lycopersicum L.Plant cell reports · 2026Article
- Harnessing genomics for fast development and commercial introduction of high-resistant tomato varieties to Tomato Brown Rugose Fruit Virus.Breeding science · 2026Article
- Tomato Brown Rugose Fruit Virus Evades Tm-2Molecular plant pathology · 2026Article
- Mild to Virulent: Coat Protein Mutations Restore Mosaic Symptom Induction in a Korean PepMV Isolate.Viruses · 2026Article
- BreedingFrontiers in plant science · 2026Article
- Rewiring of auxin and MAPK signaling is associated with contrasting shoestring and fern-like manifestations in ToBRFV-A134T-infected tomato.Frontiers in plant science · 2026Article
- The N gene protects tomato plants from tomato brown rugose fruit virus infection.Plant biotechnology journal · 2025Article
- Tm-1 back in business: an allele from Solanum pennellii accessions plays a major role in ToBRFV resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Genomic Diversity of Tomato Brown Rugose Fruit Virus in Canadian Greenhouse Production Systems.Viruses · 2025Article
- Contribution of the tobamovirus resistance gene Tm-1 to control of tomato brown rugose fruit virus (ToBRFV) resistance in tomato.PLoS genetics · 2025Article
- Molecular breeding of tomato: Advances and challenges.Journal of integrative plant biology · 2025Review
- Advances in understanding the interaction betweenPlant signaling & behavior · 2024Review
- Defense Responses Induced by Viral Movement Protein and Its Nuclear Localization Modulate Virus Cell-to-Cell Transport.Plants (Basel, Switzerland) · 2024Article
- Molecular characterization and host reaction to tomato mottle mosaic virus isolated from sweet pepper seeds in Japan.Archives of virology · 2024Article
- Plant Immunity against Tobamoviruses.Viruses · 2024Review
- Single amino acid change in tomato brown rugose fruit virus breaks virus-specific resistance in new resistant tomato cultivar.Frontiers in plant science · 2024Article
- Advances and Prospects of Virus-Resistant Breeding in Tomatoes.International journal of molecular sciences · 2023Review
- The Hypersensitive Response to Plant Viruses.Viruses · 2023Review
19 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In tomato, infections by tomato mosaic virus are controlled by durable Tm-2(2) resistance. In order to gain insight into the processes underlying disease resistance and its durability, we cloned and analysed the Tm-2(2) resistance gene and the susceptible allele, tm-2. The Tm-2(20 gene was isolated by transposon tagging using a screen in which plants with a destroyed Tm-2(2) gene survive. The Tm-2(2) locus consists of a single gene that encodes an 861 amino acid polypeptide, which belongs to the CC-NBS-LRR class of resistance proteins. The putative tm-2 allele was cloned from susceptible tomato lines via PCR with primers based on the Tm-2(2) sequence. Interestingly, the tm-2 gene has an open reading frame that is comparable to the Tm-2(2) allele. Between the tm-2 and the Tm-2(2) polypeptide 38 amino acid differences are present of which 26 are located in the second half of the LRR-domain. Susceptible tomato plants, which were transformed with the Tm-2(2) gene, displayed resistance against ToMV infection. In addition, virus specificity, displayed by the Tm-2(2) resistance was conserved in these transgenic lines. To explain the durability of this resistance, it is proposed that the Tm-2(2)-encoded resistance is aimed at the Achilles' heel of the virus.
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