ArticleAmerican journal of human genetics2003
A major susceptibility locus on chromosome 22q12 plays a critical role in the control of kala-azar.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 76 citations in OpenAlex.
- Trial
- Epitope-Binding Characteristics for Risk versus Protective DRB1 Alleles for Visceral Leishmaniasis.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Comprehensive candidate gene analysis for symptomatic or asymptomatic outcomes of Leishmania infantum infection in Brazil.Annals of human genetics · 2017Article
- Fine mapping under linkage peaks for symptomatic or asymptomatic outcomes of Leishmania infantum infection in Brazil.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Human genetic basis of interindividual variability in the course of infection.Proceedings of the National Academy of Sciences of the United States of America · 2015Review
- Immune regulation during chronic visceral leishmaniasis.PLoS neglected tropical diseases · 2014Review
- Significantly lower anti-Leishmania IgG responses in Sudanese versus Indian visceral leishmaniasis.PLoS neglected tropical diseases · 2014Article
- Lipoprotein lipase and PPAR alpha gene polymorphisms, increased very-low-density lipoprotein levels, and decreased high-density lipoprotein levels as risk markers for the development of visceral leishmaniasis by Leishmania infantum.Mediators of inflammation · 2014Article
- Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood.The Journal of experimental medicine · 2013Article
- Mapping the genes for susceptibility and response to Leishmania tropica in mouse.PLoS neglected tropical diseases · 2013Article
- Article
- Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
- Genetic evidence of functional ficolin-2 haplotype as susceptibility factor in cutaneous leishmaniasis.PloS one · 2012Article
- Genetic control of canine leishmaniasis: genome-wide association study and genomic selection analysis.PloS one · 2012Article
- Article
- Activity of trypanosome lytic factor: a novel component of innate immunity.Future microbiology · 2009Review
- Genetics and visceral leishmaniasis: of mice and man.Parasite immunology · 2009Review
- Genetic admixture in Brazilians exposed to infection with Leishmania chagasi.Annals of human genetics · 2009Article
- HLA and infectious diseases.Clinical microbiology reviews · 2009Review
- Recent developments leading toward a paradigm switch in the diagnostic and therapeutic approach to human leishmaniasis.Current opinion in infectious diseases · 2008Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kala-azar (KA) is a life-threatening protozoal disease caused by Leishmania parasites (L. donovani, L. chagasi, and L. infantum). The disease, which is also called "visceral leishmaniasis," is prevalent in Africa, South America, Asia, and the Mediterranean basin. Epidemics occur periodically, killing a large number of infected individuals. Factors determining whether a patient remains asymptomatic or develops KA are still largely unknown. In a previous study that was performed during an outbreak of KA in a village on the Ethiopian-Sudanese border, we showed that KA was more frequent in certain families and ethnic groups, thereby suggesting that host genetic factors play an important role in the development of the disease. Here, we report the results of a genomewide linkage study performed on 63 Sudanese families selected from the most affected ethnic group and including 169 children with KA. Significant linkage (LOD score 3.50 [P=3x10-5] in all patients; LOD score 3.90 [P=10-5] in patients who were affected early in the outbreak) was obtained with markers on chromosome 22q12. These results are the first evidence of a major genetic effect on the development of human KA. They may lead to identification of genes critical in the pathogenesis of this disease and to new therapeutic interventions against this parasite, which is developing resistance to available drugs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.