ReviewOncogene2003
Induced genomic instability in irradiated germ cells and in the offspring; reconciling discrepancies among the human and animal studies.
Review in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 50 citations in OpenAlex.
- Radiation-induced Non-targeted Effect and Carcinogenesis; Implications in Clinical Radiotherapy.Journal of biomedical physics & engineering · 2018Article
- Nuclear DNA fragmentation negatively affects zona binding competence of Y bearing mouse spermatozoa.Journal of assisted reproduction and genetics · 2013Article
- What mechanisms/processes underlie radiation-induced genomic instability?Cellular and molecular life sciences : CMLS · 2012Article
- Isolated spermatozoa as indicators of mutations transmitted to progeny.Mutation research · 2010Article
- Analysis of differential DNA damage in the mitochondrial genome employing a semi-long run real-time PCR approach.Nucleic acids research · 2010Article
- Association between the extent of DNA damage in the spermatozoa, fertilization and developmental competence in preimplantation stage embryos.Journal of the Turkish German Gynecological Association · 2010Article
- Ionizing radiation and childhood leukemia.Environmental health perspectives · 2007Article
- New germline mutations in the hypervariable minisatellite CEB1 in the parents of children with leukaemia.British journal of cancer · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many studies confirmed that radiation induces genomic instability in whole-body systems. However, the results of the studies are not always consistent with each other. Attempts are made in the present review to resolve the discrepancies. Many of the studies in human and experimental animals utilize the length change mutation of minisatellite sequences as a marker of genomic instability. Minisatellite sequences frequently change their length, and the data obtained by conventional Southern blotting give rather qualitative information, which is sometimes difficult to scrutinize quantitatively. This is the problem inevitably associated with the study of minisatellite mutations and the source of some conflicts among studies in humans and mice. Radiation induction of genomic instability has also been assessed in whole-body experimental systems, using other markers such as the mouse pink-eyed unstable allele and the specific pigmentation loci of medaka fish (Oryzias latipes). Even though there are some contradictions, all these studies have demonstrated that genomic instability is induced in the germ cells of irradiated parents, especially of males, and in offspring born to them. Among these, transmission of genomic instability to the second generation of irradiated parents is limited to the mouse minisatellite system, and awaits further clarification in other experimental systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.