ArticleOncogene2003
Genomic instability and bystander effects: a historical perspective.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 208 citations in OpenAlex.
- Fluorescence and phosphorescence lifetime imaging reveals a significant cell nuclear viscosity and refractive index changes upon DNA damage.Scientific reports · 2023Article
- The intercellular communications mediating radiation-induced bystander effects and their relevance to environmental, occupational, and therapeutic exposures.International journal of radiation biology · 2023Review
- Non-canonical roles of apoptotic and DNA double-strand break repair factors in mediating cellular response to ionizing radiation.International journal of radiation biology · 2023Review
- Radium-223-Induced Bystander Effects Cause DNA Damage and Apoptosis in Disseminated Tumor Cells in Bone Marrow.Molecular cancer research : MCR · 2021Article
- Boron neutron capture therapy: Current status and future perspectives.Cancer communications (London, England) · 2020Review
- LINE-1 hypomethylation is associated with radiation-induced genomic instability in industrial radiographers.Environmental and molecular mutagenesis · 2019Article
- Enhancing the Bystander and Abscopal Effects to Improve Radiotherapy Outcomes.Frontiers in oncology · 2019Review
- Radiation shielding parameters of some antioxidants using Monte Carlo method.Journal of biological physics · 2018Article
- Carcinogenesis Induced by Low-dose Radiation.Radiology and oncology · 2017Article
- Genomic instability induced in distant progeny of bystander cells depends on the connexins expressed in the irradiated cells.International journal of radiation biology · 2017Article
- The role of protein kinase C alpha translocation in radiation-induced bystander effect.Scientific reports · 2016Article
- Delayed Numerical Chromosome Aberrations in Human Fibroblasts by Low Dose of Radiation.International journal of environmental research and public health · 2015Article
- Contrasting roles for C/EBPα and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects.Stem cells (Dayton, Ohio) · 2015Article
- Indirect effects of radiation induce apoptosis and neuroinflammation in neuronal SH-SY5Y cells.Neurochemical research · 2014Article
- 3-Methyl pyruvate enhances radiosensitivity through increasing mitochondria-derived reactive oxygen species in tumor cell lines.Journal of radiation research · 2014Article
- Health risks of space exploration: targeted and nontargeted oxidative injury by high-charge and high-energy particles.Antioxidants & redox signaling · 2014Review
- Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis.Mutation research. Reviews in mutation research · 2014Review
- Radiation-Induced Bystander Response: Mechanism and Clinical Implications.Advances in wound care · 2014Review
- Gap junction communication and the propagation of bystander effects induced by microbeam irradiation in human fibroblast cultures: the impact of radiation quality.Radiation research · 2013Article
- Nontargeted stressful effects in normal human fibroblast cultures exposed to low fluences of high charge, high energy (HZE) particles: kinetics of biologic responses and significance of secondary radiations.Radiation research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Data have been emerging over the past two decades concerning two phenomena in which important biological effects of ionizing radiation arise in cells that in themselves receive no radiation exposure. In the first, radiation-induced genomic instability, biological effects occur in the progeny of the irradiated cell after many generations of cell division. In the second, radiation-induced bystander effects, they arise in cells that receive no radiation exposure as a consequence of damage signals transmitted from neighboring irradiated cells; transmission may be mediated either by direct intercellular communication through gap junctions, or by factors released into the surrounding medium. In both phenomena, the biological effects appear to be associated with an upregulation of oxidative metabolism. The present paper is designed to review the historical background leading to our current knowledge of these two phenomena, and to indicate some future directions for research that will allow us to assess better their importance in the health effects of exposure to ionizing radiation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.