ArticleJournal of virology2003
Murine cytomegalovirus m41 open reading frame encodes a Golgi-localized antiapoptotic protein.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Recent Approaches and Strategies in the Generation of Anti-human Cytomegalovirus Vaccines.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Human cytomegalovirus glycoprotein B variants affect viral entry, cell fusion, and genome stability.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- UL36 Rescues Apoptosis Inhibition andFrontiers in cellular and infection microbiology · 2017Article
- Inactivation of the Human Cytomegalovirus US20 Gene Hampers Productive Viral Replication in Endothelial Cells.Journal of virology · 2015Article
- Structural biology of the Bcl-2 family and its mimicry by viral proteins.Cell death & disease · 2013Review
- Gene products of the embedded m41/m41.1 locus of murine cytomegalovirus differentially influence replication and pathogenesis.Virology · 2013Article
- MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication.PLoS pathogens · 2013Article
- Cytomegalovirus downregulates IRE1 to repress the unfolded protein response.PLoS pathogens · 2013Article
- Live or let die: manipulation of cellular suicide programs by murine cytomegalovirus.Medical microbiology and immunology · 2012Review
- Prevention of cellular suicide by cytomegaloviruses.Viruses · 2012Review
- The US16 gene of human cytomegalovirus is required for efficient viral infection of endothelial and epithelial cells.Journal of virology · 2012Article
- The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1.Journal of virology · 2012Article
- Viral mediated redirection of NEMO/IKKγ to autophagosomes curtails the inflammatory cascade.PLoS pathogens · 2012Article
- A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection.PLoS pathogens · 2011Article
- Mutations in the M112/M113-coding region facilitate murine cytomegalovirus replication in human cells.Journal of virology · 2010Article
- Characterization of a novel Golgi apparatus-localized latency determinant encoded by human cytomegalovirus.Journal of virology · 2009Article
- Essential role for either TRS1 or IRS1 in human cytomegalovirus replication.Journal of virology · 2009Article
- Specific inhibition of the PKR-mediated antiviral response by the murine cytomegalovirus proteins m142 and m143.Journal of virology · 2009Article
- Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention.Clinical microbiology reviews · 2009Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Viruses have evolved various strategies to prevent premature apoptosis of infected host cells. Some of the viral genes mediating antiapoptotic functions have been identified by their homology to cellular genes, but others are structurally unrelated to genes of known function. In this study, we used a random, unbiased approach to identify such genes in the murine cytomegalovirus genome. From a library of random transposon insertion mutants, a mutant virus that caused premature cell death was isolated. The transposon was inserted within open reading frame m41. An independently constructed m41 deletion mutant showed the same phenotype, whereas deletion mutants lacking the adjacent genes m40 and M42 did not. Apoptosis occurred in different cell types, could be blocked by caspase inhibitors, and did not require p53. Within the murine cytomegalovirus genome, m41, m40, and m39 form a small cluster of genes of unknown function. They are homologous to r41, r40, and r39 of rat cytomegalovirus, but lack sequence homology to UL41, UL40, and UL37 exon 1 (UL37x1) which are located at the corresponding positions of the human cytomegalovirus genome. Unlike UL37x1 of human cytomegalovirus, which encodes a mitochondrion-localized inhibitor of apoptosis that is essential for virus replication, m41 encodes a protein that localizes to the Golgi apparatus. The murine cytomegalovirus m41 product is the first example of a Golgi-localized protein that prevents premature apoptosis and thus extends the life span of infected cells.
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