ArticleJournal of virology2003
Structure and expression of mobile ETnII retroelements and their coding-competent MusD relatives in the mouse.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Activation of endogenous retroviruses characterizes the maternal-fetal interface in the BTBR mouse model of autism spectrum disorder.Scientific reports · 2025Article
- An old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development.Molecular psychiatry · 2023Article
- Neonatal lethality of mouse A/J-7Mammalian genome : official journal of the International Mammalian Genome Society · 2023Article
- Differential Expression of Endogenous Retroviruses and Inflammatory Mediators in Female and Male Offspring in a Mouse Model of Maternal Immune Activation.International journal of molecular sciences · 2022Article
- KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage.eLife · 2020Article
- Mouse germ line mutations due to retrotransposon insertions.Mobile DNA · 2019Review
- Tie-Break: Host and Retrotransposons Play tRNA.Trends in cell biology · 2018Review
- High expression of Endogenous Retroviruses from intrauterine life to adulthood in two mouse models of Autism Spectrum Disorders.Scientific reports · 2018Article
- Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice.PLoS genetics · 2017Article
- piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells.Genes & development · 2014Article
- Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human.Nature neuroscience · 2014Article
- Identification of both copy number variation-type and constant-type core elements in a large segmental duplication region of the mouse genome.BMC genomics · 2013Article
- Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases.Frontiers in microbiology · 2013Article
- A novel intergenic ETnII-β insertion mutation causes multiple malformations in polypodia mice.PLoS genetics · 2013Article
- Expression of endogenous retroviruses is negatively regulated by the pluripotency marker Rex1/Zfp42.Nucleic acids research · 2012Article
- Mutation of Rubie, a novel long non-coding RNA located upstream of Bmp4, causes vestibular malformation in mice.PloS one · 2012Article
- Retrofitting the genome: L1 extinction follows endogenous retroviral expansion in a group of muroid rodents.Journal of virology · 2011Article
- Retrotransposon-induced heterochromatin spreading in the mouse revealed by insertional polymorphisms.PLoS genetics · 2011Article
- H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing.Epigenetics & chromatin · 2011Article
- Organomegaly and tumors in transgenic mice with targeted expression of HpaII methyltransferase in smooth muscle cells.Epigenetics · 2011Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ETnII elements are mobile members of the repetitive early transposon family of mouse long terminal repeat (LTR) retroelements and have caused a number of mutations by inserting into genes. ETnII sequences lack retroviral genes, but the recent discovery of related MusD retroviral elements with regions similar to gag, pro, and pol suggests that MusD provides the proteins necessary for ETnII transposition in trans. For this study, we analyzed all ETnII elements in the draft sequence of the C57BL/6J genome and classified them into three subtypes (alpha, beta, and gamma) based on structural differences. We then used database searches and quantitative real-time PCR to determine the copy number and expression of ETnII and MusD elements in various mouse strains. In 7.5-day-old embryos of a mouse strain in which two mutations due to ETnII-beta insertions have been identified (SELH/Bc), we detected a three- to sixfold higher level of ETnII-beta and MusD transcripts than in control strains (C57BL/6J and LM/Bc). The increased ETnII transcription level can in part be attributed to a higher number of ETnII-beta elements, but 70% of the MusD transcripts appear to have been derived from one or a few MusD elements that are not detectable in C57BL/6J mice. This element belongs to a young MusD subgroup with intact open reading frames and identical LTRs, suggesting that the overexpressed element(s) in SELH/Bc mice might provide the proteins for the retrotransposition of ETnII and MusD elements. We also show that ETnII is expressed up to 30-fold more than MusD, which could explain why only ETnII, but not MusD, elements have been positively identified as new insertions.
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