Evidence map›Paper›PMID 14557618›Full record

ArticleJournal of virology2003

Feline foamy virus genome and replication strategy.

Jacqueline Roy, Wolfram Rudolph, Thomas Juretzek, Kathleen Gärtner, Michael Bock, Ottmar Herchenröder, Dirk Lindemann, Martin Heinkelein, Axel Rethwilm

Abstract read
In one paragraph

Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
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  15. Review
  16. Article
  17. Article
  18. Nonintegrating foamy virus vectors.Journal of virology · 2010
    Article
  19. Molecular biology of foamy viruses.Medical microbiology and immunology · 2010
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jacqueline RoyInstitut für Virologie, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Wolfram Rudolph
Thomas Juretzek
Kathleen Gärtner
Michael Bock
Ottmar Herchenröder
Dirk Lindemann
Martin Heinkelein
Axel Rethwilm

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crucial aspects of the foamy virus (FV) replication strategy have so far only been investigated for the prototypic FV (PFV) isolate, which is supposed to be derived from nonhuman primates. To study whether the unusual features of this replication pathway also apply to more-distantly related FVs, we constructed feline FV (FFV) infectious molecular clones and vectors. It is shown by quantitative RNA and DNA PCR analysis that FFV virions contain more RNA than DNA. Full-length linear DNA was found in extracellular FFV by Southern blot analysis. Similar to PFV, azidothymidine inhibition experiments and the transfection of nucleic acids extracted from extracellular FFV indicated that DNA is the functional relevant FFV genome. Unlike PFV, no evidence was found indicating that FFV recycles its DNA into the nucleus.

Indexed as

Genome, ViralVirus ReplicationAnimalsCatsCell LineCricetinaeDNA, ViralHumansMiceMolecular Sequence DataPolymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, ViralSequence Analysis, DNASpumavirusTransfectionDNA, ViralRNA, Viral

Identifiers

PMID14557618
PMCPMC229293

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.