ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Quantitation of contacts among sensory, motor, and serotonergic neurons in the pedal ganglion of aplysia.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Cellular-resolution gene expression mapping reveals organization in the head ganglia of the gastropod, Berghia stephanieae.The Journal of comparative neurology · 2024Article
- Characterization of Neuronal RNA Modifications during Non-associative Learning inACS central science · 2021Article
- Possible novel features of synaptic regulation during long-term facilitation inLearning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Autaptic muscarinic self-excitation and nitrergic self-inhibition in neurons initiating Aplysia feeding are revealed when the neurons are cultured in isolation.Journal of molecular histology · 2012Article
- Long-lasting synaptic potentiation induced by depolarization under conditions that eliminate detectable Ca2+ signals.Journal of neurophysiology · 2010Article
- New tricks for an old slug: the critical role of postsynaptic mechanisms in learning and memory in Aplysia.Progress in brain research · 2008Review
- Synaptic plasticity in myenteric neurons of the guinea-pig distal colon: presynaptic mechanisms of inflammation-induced synaptic facilitation.The Journal of physiology · 2007Article
- Regulation of behavioral and synaptic plasticity by serotonin release within local modulatory fields in the CNS of Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Synaptic facilitation and behavioral dishabituation in Aplysia: dependence on release of Ca2+ from postsynaptic intracellular stores, postsynaptic exocytosis, and modulation of postsynaptic AMPA receptor efficacy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Differential role of inhibition in habituation of two independent afferent pathways to a common motor output.Learning & memory (Cold Spring Harbor, N.Y.)Article
- The "prawn-in-the-tube" procedure in the cuttlefish: habituation or passive avoidance learning?Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Present models of long-term sensitization in Aplysia californica indicate that the enhanced behavioral response is due, at least in part, to outgrowth of sensory neurons mediating defensive withdrawal reflexes. Presumably, this outgrowth strengthens pre-existing connections by formation of new synapses with follower neurons. However, the relationship between the number of sensorimotor contacts and the physiological strength of the connection has never been examined in intact ganglia. As a first step in addressing this issue, we used confocal microscopy to examine sites of contact between sensory and motor neurons in naive animals. Our results revealed relatively few contacts between physiologically connected cells. In addition, the number of contact sites was proportional to the amplitude of the EPSP elicited in the follower motor neuron by direct stimulation of the sensory neuron. This is the first time such a correlation has been observed in the central nervous system. Serotonin is the neurotransmitter most closely examined for its role in modulating synaptic strength at the sensorimotor synapse. However, the structural relationship of serotonergic processes and sensorimotor synapses has never been examined. Surprisingly, serotonergic processes usually made contact with sensory and motor neurons at sites located relatively distant from the sensorimotor synapse. This result implies that heterosynaptic regulation is due to nondirected release of serotonin into the neuropil.
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