ArticleProceedings of the National Academy of Sciences of the United States of America2003
Contrasting patterns of expression of transcription factors in pancreatic alpha and beta cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Transcriptome analysis of mammary epithelial cell between Sewa sheep and East FriEsian sheep from different localities.BMC genomics · 2024Article
- A Supportive Role of Mesenchymal Stem Cells on Insulin-Producing Langerhans Islets with a Specific Emphasis on The Secretome.Biomedicines · 2023Review
- Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer.Frontiers in endocrinology · 2020Review
- Paracrine GABA and insulin regulate pancreatic alpha cell proliferation in a mouse model of type 1 diabetes.Diabetologia · 2017Article
- Cancer risks among patients with type 2 diabetes: a 10-year follow-up study of a nationwide population-based cohort in Taiwan.BMC cancer · 2014Article
- Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice.Diabetologia · 2013Article
- Article
- Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection.Nature biotechnology · 2009Article
- Characterization of the mouse pancreatic islet proteome and comparative analysis with other mouse tissues.Journal of proteome research · 2008Article
- Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Gene therapy progress and prospects: gene therapy for diabetes mellitus.Gene therapy · 2005Review
- Role for activating transcription factor 3 in stress-induced beta-cell apoptosis.Molecular and cellular biology · 2004Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Pancreatic alpha and beta cells are derived from the same progenitors but play opposing roles in the control of glucose homeostasis. Disturbances in their function are associated with diabetes mellitus. To identify many of the proteins that define their unique pathways of differentiation and functional features, we have analyzed patterns of gene expression in alphaTC1.6 vs. MIN6 cell lines by using oligonucleotide microarrays. Approximately 9-10% of >11,000 transcripts examined showed significant differences between the two cell types. Of >700 known transcripts enriched in either cell type, transcription factors and their regulators (TFR) was one of the most significantly different categories. Ninety-six members of the basic zipper, basic helix-loop-helix, homeodomain, zinc finger, high mobility group, and other transcription factor families were enriched in alpha cells; in contrast, homeodomain proteins accounted for 51% of a total of 45 TFRs enriched in beta cells. Our analysis thus highlights fundamental differences in expression of TFR subtypes within these functionally distinct islet cell types. Interestingly, the alpha cells appear to express a large proportion of factors associated with progenitor or stem-type cells, perhaps reflecting their earlier appearance during pancreatic development. The implications of these findings for a better understanding of alpha and beta cell dysfunction in diabetes mellitus are also considered.
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