ReviewClinical microbiology reviews2003
Current perspectives on ophthalmic mycoses.
Review in Clinical microbiology reviews, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
134 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fungal Keratitis Caused by Colletotrichum dematium: Case Study and Review.Mycopathologia · 2019Pooled it
- A five-year survey of dematiaceous fungi in a tropical hospital reveals potential opportunistic species.PloS one · 2014Trial
- Natamycin in the treatment of keratomycosis: correlation of treatment outcome and in vitro susceptibility of fungal isolates.Indian journal of ophthalmologyTrial
- Trichosporon ocular infections: Genotyping, antifungal susceptibility, clinico-microbiological correlation, and literature review.Indian journal of ophthalmology · 2026Review
- Prevalence, Etiology, and Antifungal Resistance Profiles of Ocular Fungal Infections in Ghanaian Ophthalmic Patients: A Multicenter Cross-Sectional Study.Health science reports · 2026Article
- A thirteen-year tertiary centre experience with infectious keratitis in the elderly population.International ophthalmology · 2026Article
- Fungal keratitis: Does antifungal Resistance Influence the outcome?International ophthalmology · 2025Article
- Idiopathic Fusarium Sclerouveitis: A Case Report.Cornea · 2025Article
- Causative Agents of Fungal Keratitis in Northeastern Iran: A 3-Year Tertiary Care Hospital Study.The American journal of tropical medicine and hygiene · 2025Article
- Atypical conjunctival sporotrichosis secondary to Mooren's ulcer: a case report.BMC infectious diseases · 2025Article
- Pseudonectria keratitis-emerging pathogenic fungi in the eye.Annals of clinical microbiology and antimicrobials · 2024Article
- Invasive Fungal Infections of the Head and Neck: A Tertiary Hospital Experience.Pathogens (Basel, Switzerland) · 2024Article
- From Clinical Suspicion to Diagnosis: A Review of Diagnostic Approaches and Challenges in Fungal Keratitis.Journal of clinical medicine · 2024Review
- Infectious and Noninfectious Corneal Ulcers in Ocular Graft-Versus-Host Disease: Epidemiology, Clinical Characteristics, and Outcomes.American journal of ophthalmology · 2024Article
- Zeolitic Imidazolate Framework-8 Offers an Anti-Inflammatory and Antifungal Method in the Treatment ofInternational journal of nanomedicine · 2024Article
- Updates in Diagnostic Imaging for Infectious Keratitis: A Review.Diagnostics (Basel, Switzerland) · 2023Review
- A Structure-Aware Convolutional Neural Network for Automatic Diagnosis of Fungal Keratitis with In Vivo Confocal Microscopy Images.Journal of digital imaging · 2023Article
- An artificial intelligence approach to classify pathogenic fungal genera of fungal keratitis using corneal confocal microscopy images.International ophthalmology · 2023Article
- Eye fungal infections: a mini review.Archives of microbiology · 2023Review
- Oral voriconazole monotherapy for fungal keratitis: efficacy, safety, and factors associated with outcomes.Frontiers in medicine · 2023Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungi may infect the cornea, orbit and other ocular structures. Species of Fusarium, Aspergillus, Candida, dematiaceous fungi, and Scedosporium predominate. Diagnosis is aided by recognition of typical clinical features and by direct microscopic detection of fungi in scrapes, biopsy specimens, and other samples. Culture confirms the diagnosis. Histopathological, immunohistochemical, or DNA-based tests may also be needed. Pathogenesis involves agent (invasiveness, toxigenicity) and host factors. Specific antifungal therapy is instituted as soon as the diagnosis is made. Amphotericin B by various routes is the mainstay of treatment for life-threatening and severe ophthalmic mycoses. Topical natamycin is usually the first choice for filamentous fungal keratitis, and topical amphotericin B is the first choice for yeast keratitis. Increasingly, the triazoles itraconazole and fluconazole are being evaluated as therapeutic options in ophthalmic mycoses. Medical therapy alone does not usually suffice for invasive fungal orbital infections, scleritis, and keratitis due to Fusarium spp., Lasiodiplodia theobromae, and Pythium insidiosum. Surgical debridement is essential in orbital infections, while various surgical procedures may be required for other infections not responding to medical therapy. Corticosteroids are contraindicated in most ophthalmic mycoses; therefore, other methods are being sought to control inflammatory tissue damage. Fungal infections following ophthalmic surgical procedures, in patients with AIDS, and due to use of various ocular biomaterials are unique subsets of ophthalmic mycoses. Future research needs to focus on the development of rapid, species-specific diagnostic aids, broad-spectrum fungicidal compounds that are active by various routes, and therapeutic modalities which curtail the harmful effects of fungus- and host tissue-derived factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.