ReviewClinical microbiology reviews2003
Antigens and alternatives for control of Anaplasma marginale infection in cattle.
Review in Clinical microbiology reviews, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
132 citing papers in PubMed, 3 syntheses or guidelines pooled it, 399 citations in OpenAlex.
- Human granulocytotropic anaplasmosis-A systematic review and analysis of the literature.PLoS neglected tropical diseases · 2024Pooled it
- Current status of ruminant anaplasmosis in Algeria: a systematic review and meta-analysis.Tropical animal health and production · 2024Pooled it
- Systematic Review and Meta-Analysis on Piroplasma spp. Infection and Co-infection with Anaplasma marginale in Domestic Ruminants from Algeria.Acta parasitologica · 2024Pooled it
- Comparison of iatrogenic transmission of Anaplasma marginale in Holstein steers via needle and needle-free injection techniques.American journal of veterinary research · 2010Trial
- Molecular Detection of Anaplasma marginale in the Central Region of Venezuela: A PCR-based Assessment of the msp2 and msp5 Genes.Acta parasitologica · 2026Article
- Molecular detection and characterization of Anaplasma marginale in cattle from the Lower Shabelle Region of Somalia.Parasites & vectors · 2026Article
- Development and evaluation of a lateral flow assay for detecting Anaplasma marginale infection in cattle.Veterinary research communications · 2026Article
- High Molecular Prevalence of Anaplasma spp. in Cattle from the Sertão and Agreste Regions, Northeast Brazil.Acta parasitologica · 2026Article
- Tick Microbiome and Its Role in Emerging Zoonotic Diseases and Transmissibility.Microorganisms · 2026Review
- Demonstration of Anaplasma marginale transmission to cattle through the intra-transstadial and by unfed larvae of Rhipicephalus microplus routes, with subsequent calculation of infection rates.Tropical animal health and production · 2026Article
- Article
- Haematology, serum biochemistry, innate and adaptive immune system responses to blood pathogen infections in cattle: A review.Parasitology research · 2026Review
- The 'teabag method': tick feeding protocol and the effects of tick feeding on hematological parameters in the canine host.Parasites & vectors · 2026Article
- Unveiling the tick-borne pathogens from domestic ruminant ticks in Malawi and the emergence of the brown ear tick in the southern region: implications for East Coast fever control.Parasite (Paris, France) · 2026Article
- Nomenclature, classification, and in-silico structural analysis of MSP1a variants of Anaplasma marginale.PloS one · 2026Article
- Behavioral manipulation ofmBio · 2025Article
- High Prevalence and Genetic Heterogeneity ofPathogens (Basel, Switzerland) · 2025Article
- The Bacterial and pathogenic landscape of African buffalo (Syncerus caffer) whole blood and serum from Kenya.Animal microbiome · 2025Article
- Propagation dynamics of Anaplasma marginale in a Brazilian tick cell line (RBME-6) derived from Rhipicephalus microplus.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2025Article
- Anaplasmosis in the Amazon: diagnostic challenges, persistence, and control ofFrontiers in veterinary science · 2025Review
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anaplasmosis, a tick-borne cattle disease caused by the rickettsia Anaplasma marginale, is endemic in tropical and subtropical areas of the world. The disease causes considerable economic loss to both the dairy and beef industries worldwide. Analyses of 16S rRNA, groESL, and surface proteins have resulted in the recent reclassification of the order Rickettsiales. The genus Anaplasma, of which A. marginale is the type species, now also includes A. bovis, A. platys, and A. phagocytophilum, which were previously known as Ehrlichia bovis, E. platys, and the E. phagocytophila group (which causes human granulocytic ehrlichiosis), respectively. Live and killed vaccines have been used for control of anaplasmosis, and both types of vaccines have advantages and disadvantages. These vaccines have been effective in preventing clinical anaplasmosis in cattle but have not blocked A. marginale infection. Thus, persistently infected cattle serve as a reservoir of infective blood for both mechanical transmission and infection of ticks. Advances in biochemical, immunologic, and molecular technologies during the last decade have been applied to research of A. marginale and related organisms. The recent development of a cell culture system for A. marginale provides a potential source of antigen for the development of improved killed and live vaccines, and the availability of cell culture-derived antigen would eliminate the use of cattle in vaccine production. Increased knowledge of A. marginale antigen repertoires and an improved understanding of bovine cellular and humoral immune responses to A. marginale, combined with the new technologies, should contribute to the development of more effective vaccines for control and prevention of anaplasmosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.