ArticlePflugers Archiv : European journal of physiology2003
Mitochondria and release at hippocampal synapses.
Article in Pflugers Archiv : European journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Mitochondria at the neuronal presynapse in health and disease.Nature reviews. Neuroscience · 2018Review
- Live Imaging Mitochondrial Transport in Neurons.Neuromethods · 2017Article
- Micropatterning Facilitates the Long-Term Growth and Analysis of iPSC-Derived Individual Human Neurons and Neuronal Networks.Advanced healthcare materials · 2016Article
- Glycolytic Enzymes Localize to Synapses under Energy Stress to Support Synaptic Function.Neuron · 2016Article
- Mitochondrial Calcium Uptake Modulates Synaptic Vesicle Endocytosis in Central Nerve Terminals.The Journal of biological chemistry · 2016Article
- Transporting mitochondria in neurons.F1000Research · 2016Review
- The role of mitochondrially derived ATP in synaptic vesicle recycling.The Journal of biological chemistry · 2015Article
- Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease.Neurobiology of disease · 2013Review
- Synaptic vesicle exocytosis in hippocampal synaptosomes correlates directly with total mitochondrial volume.Journal of molecular neuroscience : MN · 2013Article
- The meaning of mitochondrial movement to a neuron's life.Biochimica et biophysica acta · 2013Review
- Imaging axonal transport of mitochondria.Methods in enzymology · 2009Article
- Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Use-dependent control of presynaptic calcium signalling at central synapses.Journal of anatomy · 2007Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondria are present in some, but not all presynaptic terminals in the hippocampus. Mitochondria are capable of sequestering and storing large amounts of calcium, but it is unclear whether they influence release probability at these synapses. Using FM dye imaging techniques and confocal microscopy, we have examined the relationship between mitochondrial presence/absence and presynaptic vesicle release from rat hippocampal neurones in primary dissociated culture at room temperature. Following staining with the mitochondrial dye mitotracker green, we were able to resolve putative individual mitochondria associated with neuronal processes. The majority of mitochondria were positionally stable, although some exhibited periods of rapid motility (up to 0.4 microm/s) interspersed with periods of immobility. Co-staining with mitotracker green and the synaptic vesicle dye FM 4-64 indicated that 180 of 506 (36%) synapses were devoid of mitochondria. A comparison of vesicular release in response to stimulation at 1 Hz and at 10 Hz revealed no differences in release properties between synapses with and without mitochondria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.