ArticleProceedings of the National Academy of Sciences of the United States of America2003
A genetic lesion that arrests plasma cell homing to the bone marrow.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
- Identification and characterization of CXCL13 producers in bone tissue in response to fasting.International immunology · 2026Article
- Quantitative systems pharmacology model of B cell immune response in mouse.Frontiers in immunology · 2026Article
- Contribution of long-lived plasma cells to antibody-mediated allograft rejection.Clinical transplantation and research · 2024Review
- Biochemical coordination of plasma cell genesis.Immunological reviews · 2021Review
- Epigenetic gene regulation in plasma cells.Immunological reviews · 2021Review
- An Inflammatory Loop Between Spleen-Derived Myeloid Cells and CD4Frontiers in immunology · 2021Article
- Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice.Science translational medicine · 2020Article
- Effects of skeletal unloading on the bone marrow antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice.Life sciences in space research · 2019Article
- Staphylococcus aureus Protein A Disrupts Immunity Mediated by Long-Lived Plasma Cells.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Bruton's Tyrosine Kinase, a Component of B Cell Signaling Pathways, Has Multiple Roles in the Pathogenesis of Lupus.Frontiers in immunology · 2017Review
- Live attenuated Salmonella displaying HIV-1 10E8 epitope on fimbriae: systemic and mucosal immune responses in BALB/c mice by mucosal administration.Scientific reports · 2016Article
- Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity.Journal of autoimmunity · 2015Article
- Genetic and cellular dissection of the activation of AM14 rheumatoid factor B cells in a mouse model of lupus.Journal of leukocyte biology · 2015Article
- Regulation of the development of the hepatic B cell compartment during Schistosoma mansoni infection.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- IFN-α confers resistance of systemic lupus erythematosus nephritis to therapy in NZB/W F1 mice.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Cyclin-dependent kinase inhibitor Cdkn2c regulates B cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Targeting the bone marrow in Waldenstrom macroglobulinemia.Clinical lymphoma, myeloma & leukemia · 2011Review
- Interferon-α induces unabated production of short-lived plasma cells in pre-autoimmune lupus-prone (NZB×NZW)F1 mice but not in BALB/c mice.European journal of immunology · 2011Article
- Autoreactive marginal zone B cells enter the follicles and interact with CD4+ T cells in lupus-prone mice.BMC immunology · 2011Article
- Interferon-α accelerates murine systemic lupus erythematosus in a T cell-dependent manner.Arthritis and rheumatism · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The coordinated regulation of chemokine responsiveness plays a critical role in the development of humoral immunity. After antigen challenge and B cell activation, the emerging plasma cells (PCs) undergo CXCL12-induced chemotaxis to the bone marrow, where they produce Ab and persist. Here we show that PCs, but not B cells or T cells from lupus-prone NZM mice, are deficient in CXCL12-induced migration. PC unresponsiveness to CXCL12 results in a marked accumulation of PCs in the spleen of mice, and a concordant decrease in bone marrow PCs. Unlike normal mice, in NZM mice, a majority of the splenic PCs are long-lived. This deficiency is a consequence of the genetic interactions of multiple systemic lupus erythematosus susceptibility loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.