ArticleThe Journal of physiology2003
Acute stress modulates the histamine content of mast cells in the gastrointestinal tract through interleukin-1 and corticotropin-releasing factor release in rats.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 76 citations in OpenAlex.
- Histamine Intolerance Through a Functional Medicine Lens: A Systems-Based Review.Integrative medicine (Encinitas, Calif.) · 2026Article
- Neuroimmune connections between corticotropin-releasing hormone and mast cells: novel strategies for the treatment of neurodegenerative diseases.Neural regeneration research · 2021Review
- Article
- The multicomponent medication Spascupreel attenuates stress-induced gut dysfunction in rats.Neurogastroenterology and motility · 2020Article
- Psychological Stress, Intestinal Barrier Dysfunctions, and Autoimmune Disorders: An Overview.Frontiers in immunology · 2020Review
- Eosinophilic gastroenteritis: diagnosis and clinical perspectives.Clinical and experimental gastroenterology · 2019Review
- Brain and Gut CRF Signaling: Biological Actions and Role in the Gastrointestinal Tract.Current molecular pharmacology · 2018Review
- Repeated Water Avoidance Stress Alters Mucosal Mast Cell Counts, Interleukin-1β Levels with Sex Differences in the Distal Colon of Wistar Rats.Journal of neurogastroenterology and motility · 2016Article
- The role of AST-120 and protein-bound uremic toxins in irritable bowel syndrome: a therapeutic perspective.Therapeutic advances in gastroenterology · 2015Review
- Role of Corticotropin-releasing Factor Signaling in Stress-related Alterations of Colonic Motility and Hyperalgesia.Journal of neurogastroenterology and motility · 2015Article
- Key role of CRF in the skin stress response system.Endocrine reviews · 2013Review
- Effect of acute stress on immune cell counts and the expression of tight junction proteins in the duodenal mucosa of rats.Gut and liver · 2013Article
- Corticotrophin-releasing factor, related peptides, and receptors in the normal and inflamed gastrointestinal tract.Frontiers in neuroscience · 2011Article
- Pattern of irritable bowel syndrome and its impact on quality of life in primary health care center attendees, Suez governorate, Egypt.The Pan African medical journal · 2011Article
- Stress-induced alterations in mast cell numbers and proteinase-activated receptor-2 expression of the colon: role of corticotrophin-releasing factor.Journal of Korean medical science · 2010Article
- Antimicrobial anxiety: the impact of stress on antimicrobial immunity.Journal of leukocyte biology · 2010Review
- From Hans Selye's discovery of biological stress to the identification of corticotropin-releasing factor signaling pathways: implication in stress-related functional bowel diseases.Annals of the New York Academy of Sciences · 2008Review
- Is irritable bowel syndrome an inflammatory disorder?Current gastroenterology reports · 2008Review
- Article
- Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum.Gut · 2007Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress results in activation of the hypothalamic pituitary adrenal axis and affects illnesses such as neuroinflammatory syndrome. In vivo acute stress (restraint stress) induces gastrointestinal function disturbances through colonic mast cell activation. This study investigated the effect of acute stress in histamine content of colonic mast cells, and the central role of interleukin-1 (IL-1) and corticotropin-releasing factor (CRF) in this effect. After a restraint stress session colonic segments were isolated and submitted to three protocols: (i) determination of histamine levels by radioimmunoassay (RIA) after incubation with 48/80 compound, (ii) evaluation by histology of mucosal mast cell (MMC) number and (iii) determination of histamine immunoreactivity of MMC. These procedures were conducted (1) in sham or stressed rats, (2) in stressed rats previously treated with intracerebroventricular (I.C.V.) IL-1ra or alpha-helical CRF9-41, (3) in naive rats pretreated with I.C.V. rhIL-1beta or CRF and (4) in rats treated with central IL-1beta and CRF plus alpha-helical CRF and IL-1ra, respectively (cross-antagonism reaction). Acute stress increases histamine content in colonic mast cells, without degranulation. I.C.V. pretreatment with IL-1ra or alpha-helical CRF9-41 blocked stress-induced mast cell histamine content increase. Both I.C.V. rhIL-1beta and CRF injections reproduced the stress-linked changes. I.C.V. treatment with CRF antagonist blocked I.C.V. rhIL-1beta-induced mast cell histamine content increase, whereas central IL-1ra did not affect stress events induced by I.C.V. CRF administration. These results suggest that in rats acute stress increases colonic mast cell histamine content. This effect is mediated by the release in cascade in the brain first of IL-1 and secondly of CRF.
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