ArticleEukaryotic cell2003
Conservation of RNase III processing pathways and specificity in hemiascomycetes.
Article in Eukaryotic cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- RNase III, Ribosome Biogenesis and Beyond.Microorganisms · 2021Review
- Stress-induced inhibition of mRNA export triggers RNase III-mediated decay of theRNA (New York, N.Y.) · 2021Article
- Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough.PLoS genetics · 2015Article
- Widespread alternative and aberrant splicing revealed by lariat sequencing.Nucleic acids research · 2015Article
- RNA recognition by double-stranded RNA binding domains: a matter of shape and sequence.Cellular and molecular life sciences : CMLS · 2013Review
- Article
- Genes come and go: the evolutionarily plastic path of budding yeast RNase III enzymes.RNA biology · 2012Review
- RNA aptamers binding the double-stranded RNA-binding domain.RNA (New York, N.Y.) · 2006Article
- Biochemical and genomic analysis of substrate recognition by the double-stranded RNA binding domain of yeast RNase III.RNA (New York, N.Y.) · 2005Article
- Yarrowia lipolytica mutants devoid of pyruvate carboxylase activity show an unusual growth phenotype.Eukaryotic cell · 2005Article
- Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA-binding domain of Rnt1p RNase III.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The roles of endonucleolytic cleavage and exonucleolytic digestion in the 5'-end processing of S. cerevisiae box C/D snoRNAs.RNA (New York, N.Y.) · 2003Article
- Recognition modes of RNA tetraloops and tetraloop-like motifs by RNA-binding proteins.Wiley interdisciplinary reviews. RNAReview
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Rnt1p, the only known Saccharomyces cerevisiae RNase III endonuclease, plays important functions in the processing of precursors of rRNAs (pre-rRNAs) and of a large number of small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs). While most eukaryotic RNases III, including the Schizosaccharomyces pombe enzyme Pac1p, cleave double-stranded RNA without sequence specificity, Rnt1p cleavage relies on the presence of terminal tetraloop structures that carry the consensus sequence AGNN. To search for the conservation of these processing signals, I have systematically analyzed predicted secondary structures of the 3' external transcribed spacer (ETS) sequences of the pre-rRNAs and of flanking sequences of snRNAs and snoRNAs from sequences available in 13 other Hemiascomycetes species. In most of these species, except in Yarrowia lipolytica, double-stranded RNA regions capped by terminal AGNN tetraloops can be found in the 3' ETS sequences of rRNA, in the 5'- or 3'-end flanking sequences of sn(o)RNAs, or in the intergenic spacers of polycistronic snoRNA transcription units. This analysis shows that RNase III processing signals and RNase III cleavage specificity are conserved in most Hemiascomycetes species but probably not in the evolutionarily more distant species Y. lipolytica.
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