ArticleEukaryotic cell2003
Alpha-pheromone-induced "shmooing" and gene regulation require white-opaque switching during Candida albicans mating.
Article in Eukaryotic cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 107 citations in OpenAlex.
- Parasex generates highly recombinant progeny in Candida albicans with increased virulence.Nature microbiology · 2026Article
- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- Article
- White-opaque switching inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Review
- Strain background ofMicrobiology (Reading, England) · 2024Article
- Exploring the role of candidalysin in the pathogenicity ofAmerican journal of translational research · 2024Article
- The Roles of Chromatin Accessibility in Regulating theJournal of fungi (Basel, Switzerland) · 2021Review
- Parasexuality ofFrontiers in cellular and infection microbiology · 2021Review
- Candida albicans Double Mutants Lacking bothmSphere · 2020Article
- Unraveling HowJournal of fungi (Basel, Switzerland) · 2020Review
- Genetic regulation of the development of mating projections inEmerging microbes & infections · 2020Article
- Roles of the Transcription Factors Sfl2 and Efg1 in White-Opaque Switching in a/α Strains of Candida albicans.mSphere · 2019Article
- Face/Off: The Interchangeable Side ofFrontiers in cellular and infection microbiology · 2019Review
- Candida albicans White-Opaque Switching Influences Virulence but Not Mating during Oropharyngeal Candidiasis.Infection and immunity · 2018Article
- Parasex Generates Phenotypic DiversityGenetics · 2017Article
- Article
- The parasexual lifestyle of Candida albicans.Current opinion in microbiology · 2015Review
- Comparison of Switching and Biofilm Formation between MTL-Homozygous Strains of Candida albicans and Candida dubliniensis.Eukaryotic cell · 2015Article
- Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A 14-mer alpha-pheromone peptide of Candida albicans was chemically synthesized and used to analyze the role of white-opaque switching in the mating process. The alpha-pheromone peptide blocked cell multiplication and induced "shmooing" in a/a cells expressing the opaque-phase phenotype but not in a/a cells expressing the white-phase phenotype. The alpha-pheromone peptide induced these effects at 25 degrees C but not at 37 degrees C. An analysis of mating-associated gene expression revealed several categories of gene regulation, including (i) MTL-homozygous-specific, pheromone stimulated, switching-independent (CAG1 and STE4); (ii) mating type-specific, pheromone-induced, switching-independent (STE2); and (iii) pheromone-induced, switching-dependent (FIG1, KAR4, and HWP1). An analysis of switching-regulated genes revealed an additional category of opaque-phase-specific genes that are downregulated by alpha-pheromone only in a/a cells (OP4, SAP1, and SAP3). These results demonstrate that alpha-pheromone causes shmooing, the initial step in the mating process, only in a/a cells expressing the opaque phenotype and only at temperatures below that in the human host. These results further demonstrate that although some mating-associated genes are stimulated by the alpha-pheromone peptide in both white- and opaque-phase cells, others are stimulated only in opaque-phase cells, revealing a category of gene regulation unique to C. albicans in which alpha-pheromone induction requires the white-opaque transition. These results demonstrate that in C. albicans, the mating process and associated gene regulation must be examined within the context of white-opaque switching.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.