ArticlePflugers Archiv : European journal of physiology2003
Dual effect of temperature on the human epithelial Na+ channel.
Article in Pflugers Archiv : European journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Aldosterone-stimulated endothelial epithelial sodium channel (EnNaC) plays a role in cold exposure-induced hypertension in rats.Frontiers in pharmacology · 2022Article
- Downregulation of epithelial sodium channel (ENaC) activity in human airway epithelia after low temperature incubation.BMJ open respiratory research · 2021Article
- Physiological mechanisms determining eccrine sweat composition.European journal of applied physiology · 2020Review
- The influence of local skin temperature on the sweat glands maximum ion reabsorption rate.European journal of applied physiology · 2019Article
- Selective Effects of Temperature on the Sensory Irritation but not Taste of NaCl and Citric Acid.Chemical senses · 2019Article
- Modulation of taste processing by temperature.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Review
- Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.Chemical senses · 2016Article
- CPT-cGMP Is A New Ligand of Epithelial Sodium Channels.International journal of biological sciences · 2016Review
- Influence of stimulus and oral adaptation temperature on gustatory responses in central taste-sensitive neurons.Journal of neurophysiology · 2015Article
- Rapid stimulation of human renal ENaC by cAMP in Xenopus laevis oocytes.Journal of physiology and biochemistry · 2013Article
- Novel determinants of epithelial sodium channel gating within extracellular thumb domains.The Journal of biological chemistry · 2009Article
- Effect of skin temperature on the ion reabsorption capacity of sweat glands during exercise in humans.European journal of applied physiology · 2005Article
- ENaC-membrane interactions: regulation of channel activity by membrane order.The Journal of general physiology · 2004Article
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Authors and funding
2 authors.
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Abstract
The amiloride-sensitive epithelial sodium channel (ENaC) is the rate-limiting step for sodium reabsorption in the distal segments of the nephron, in the colon and in the airways. Its activity is regulated by intracellular and extracellular factors but the mechanisms of this regulation are not yet completely understood. Recently, we have shown that the fast regulation of ENaC by the extracellular [Na+], a phenomenon termed self-inhibition, is temperature dependent. In the present study we examined the effects of temperature on the single-channel properties of ENaC. Single-channel recordings from excised patches showed that the channel open probability (Po, estimated from the number of open channels N.Po, where N is the total number of channels) increased on average two- to threefold while the single-channel conductance decreased by about half when the temperature of the perfusion solution was lowered from approximately 30 to approximately 15 degrees C. The effects of temperature on the single-channel conductance and Po explain the changes of the macroscopic current that can be observed upon temperature changes and, in particular, the paradoxical effect of temperature on the current carried by ENaC.
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