ArticleGenes and immunity2003
A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand.
Article in Genes and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Trial
- Cytokine gene polymorphisms implicated in the pathogenesis ofFrontiers in immunology · 2024Review
- A fine mapping of single nucleotide variants and haplotype analysis ofFrontiers in immunology · 2023Article
- Integrated Analysis of Cytokine Profiles in Malaria Patients Discloses Selective Upregulation of TGF-β1, β3, and IL-9 in Mild Clinical Presentation.International journal of molecular sciences · 2022Article
- Forward Genetics in Apicomplexa Biology: The Host Side of the Story.Frontiers in cellular and infection microbiology · 2022Review
- A genome scan for Plasmodium falciparum malaria identifies quantitative trait loci on chromosomes 5q31, 6p21.3, 17p12, and 19p13.Malaria journal · 2014Article
- Neuregulin-1 attenuates mortality associated with experimental cerebral malaria.Journal of neuroinflammation · 2014Article
- Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns.BMC infectious diseases · 2013Article
- Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels.BMC immunology · 2013Article
- Association of cytokine and Toll-like receptor gene polymorphisms with severe malaria in three regions of Cameroon.PloS one · 2013Article
- Human candidate polymorphisms in sympatric ethnic groups differing in malaria susceptibility in Mali.PloS one · 2013Article
- Article
- Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA.PLoS pathogens · 2012Article
- The host genetic diversity in malaria infection.Journal of tropical medicine · 2012Article
- Proinflammatory and regulatory cytokines and chemokines in infants with uncomplicated and severe Plasmodium falciparum malaria.Clinical and experimental immunology · 2011Article
- Distinct clinical and immunologic profiles in severe malarial anemia and cerebral malaria in Zambia.The Journal of infectious diseases · 2011Article
- Duality and complexity of allergic type inflammatory mechanisms in determining the outcome of malaria disease.Frontiers in immunology · 2011Article
- Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria.Malaria journal · 2009Article
- Interleukin13 haplotypes and susceptibility of Iranian women to breast cancer.Molecular biology reports · 2009Article
- Lack of association between interleukin-13 gene polymorphisms (-1055 C/T and +2044 G/A) in Iranian patients with lung cancer.Molecular biology reports · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined a possible association of single-nucleotide polymorphisms (SNPs) in the promoters of IL-3, IL-4, and IL-13 genes on the 5q31-33, IL-3 -16T>C, IL-4 -590T>C, and IL-13 -1055C>T, with severity of malaria in 361 adult malaria patients in Thailand. The IL-13 -1055T allele showed a significant association with protection from severe malaria (OR 0.51, 95% CI 0.32-0.80; P=0.0032 by the chi(2) test), while allele frequencies of IL-3 -16T>C and IL-4 -590T>C were not statistically different between mild and severe malaria patients. An IL-13 -1055C>T has been reported to alter the regulation of IL-13 production. Thus, IL-13 -1055T may show resistance to severe malaria through the alteration of IL-13 production.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.