ArticleGenes and immunity2003
Polymorphisms of innate immunity genes and susceptibility to lymphatic filariasis.
Article in Genes and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- The Genetic Polymorphisms of 24 Base Pair Duplication and Point G102S of Human Chitotriosidase to Bancroftian Filariasis at the Thai⁻Myanmar Border.Pathogens (Basel, Switzerland) · 2019Article
- Association of aThe American journal of tropical medicine and hygiene · 2019Article
- Human Genetic Variation and HIV/AIDS in Papua New Guinea: Time to Connect the Dots.Current HIV/AIDS reports · 2018Review
- Regulation and Role of Chitotriosidase during Lung Infection withJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- The potential role of toll-like receptor 4 Asp299Gly polymorphism and its association with recurrent cystic echinococcosis in postoperative patients.Parasitology research · 2018Article
- Does 24bp Duplication of HumanJournal of clinical and diagnostic research : JCDR · 2016Article
- Article
- High prevalence of chitotriosidase deficiency in Peruvian Amerindians exposed to chitin-bearing food and enteroparasites.Carbohydrate polymers · 2014Article
- Relevance of single-nucleotide polymorphisms in human TLR genes to infectious and inflammatory diseases and cancer.Genes and immunity · 2014Review
- Chitotriosidase deficiency: a mutation update in an african population.JIMD reports · 2013Article
- Immunopathogenesis of lymphatic filarial disease.Seminars in immunopathology · 2012Review
- Association between mannose-binding lectin polymorphisms and Wuchereria bancrofti infection in two communities in North-Eastern Tanzania.The American journal of tropical medicine and hygiene · 2010Article
- Filariasis and lymphoedema.Parasite immunology · 2009Review
- Toll-like receptor polymorphisms in malaria-endemic populations.Malaria journal · 2009Article
- Chitotriosidase deficiency is not associated with human hookworm infection in a Papua New Guinean population.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2007Article
- Human CHIT1 gene distribution: new data from Mediterranean and European populations.Journal of human genetics · 2007Article
- Human chitotriosidase polymorphisms G354R and A442V associated with reduced enzyme activity.Blood cells, molecules & diseasesArticle
- A preliminary assessment ofPapua and New Guinea medical journalArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
We examined 906 residents of an area of Papua New Guinea where bancroftian filariasis is endemic for genetic polymorphisms in three innate immunity genes suspected of contributing to susceptibility to infection and lymphatic pathology. Active infection was confirmed by the presence of blood-borne microfilariae and circulating filarial antigen in plasma. Disease was ascertained by physical examination for the presence of overt lymphedema (severe swelling of an arm or leg) or hydrocele. There was no association of infection status, lymphedema of an extremity, or hydrocele with chitotriosidase genotype (CHIT1). Polymorphisms of toll-like receptor-2 and toll-like receptor-4 genes (TLR4 A896G; TLR2 T2178A, G2258A) were not detected (N=200-625 individuals genotyped) except for two individuals heterozygous for a TLR2 mutation (C2029 T). These results indicate that a CHIT1 genotype associated previously with susceptibility to filariasis in residents of southern India and TLR2 and TLR4 polymorphisms do not correlate with infection status or disease phenotype in this Melanesian population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.