ArticleGenes and immunity2003
Haplotypic relationship between SNP and microsatellite markers at the NOS2A locus in two populations.
Article in Genes and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Further insight into the global variability of the OCA2-HERC2 locus for human pigmentation from multiallelic markers.Scientific reports · 2021Article
- Genetics of Malaria Inflammatory Responses: A Pathogenesis Perspective.Frontiers in immunology · 2019Review
- Candidate SNP markers of reproductive potential are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters.BMC genomics · 2018Article
- Inducible nitric oxide synthase 2 promoter polymorphism and malaria disease severity in children in Southern Ghana.PloS one · 2018Article
- Article
- Candidate SNP Markers of Gender-Biased Autoimmune Complications of Monogenic Diseases Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters.Frontiers in immunology · 2016Article
- Advances in genetics and genomics: use and limitations in achieving malaria elimination goals.Pathogens and global health · 2015Review
- Obesity-related known and candidate SNP markers can significantly change affinity of TATA-binding protein for human gene promoters.BMC genomics · 2015Article
- Digital genotyping of macrosatellites and multicopy genes reveals novel biological functions associated with copy number variation of large tandem repeats.PLoS genetics · 2014Article
- Rapid multiplexed genotyping of simple tandem repeats using capture and high-throughput sequencing.Human mutation · 2013Article
- Article
- Gastric cancer is associated with NOS2 -954G/C polymorphism and environmental factors in a Brazilian population.BMC gastroenterology · 2010Article
- Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes.Human genetics · 2010Article
- Influence of the inducible nitric oxide synthase gene (NOS2A) on inflammatory bowel disease susceptibility.Immunogenetics · 2007Article
- Distinct linkage disequilibrium (LD) runs of single nucleotide polymorphisms and microsatellite markers; implications for use of mixed marker haplotypes in LD-based mapping.Journal of Korean medical science · 2007Article
- Chromosome 17p12-q11 harbors susceptibility loci for systemic lupus erythematosus.Human genetics · 2004Article
- Inducible nitric oxide synthase gene (NOS2A) haplotypes and the outcome of hepatitis C virus infection.Genes and immunity · 2004Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The density of genetic markers required for successful association mapping of complex diseases depends on linkage disequilibrium (LD) between non-functional markers and functional variants. The haplotypic relationship between stable markers and potentially unstable but highly informative markers (e.g. microsatellites) indicates that LD might be maintained over considerable genetic distance in non-African populations, supporting the use of such 'mixed marker haplotypes' in LD-based mapping, and allowing inferences to be drawn about human origins. We investigated sequence variation in the proximal 2.6 kb of the inducible nitric oxide synthase (NOS2A) promoter and the relationship between SNP haplotypes and a pentanucleotide microsatellite (the 'NOS2A(-2.6) microsatellite') in Gambians and UK Caucasians. UK Caucasians exhibited a subset of sequence diversity observed in Gambians, sharing four of 11 SNPs and a similar haplotypic structure. Five SNPs were found in the sequence of interspersed repetitive DNA elements. In both populations, there was dramatic loss of LD between SNP haplotypes and microsatellite alleles across a very short physical distance, suggesting a high intrinsic mutation rate of the NOS2A(-2.6) microsatellite, the SNP haplotypes are relatively ancient, or that this was a region of frequent recombination. Understanding locus- and population-specific LD is essential when designing and interpreting genetic association studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.