ArticleGenes and immunity2003
Complex haplotypic structure of the central MHC region flanking TNF in a West African population.
Article in Genes and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians.Genes and immunity · 2013Article
- Association of cytokine and Toll-like receptor gene polymorphisms with severe malaria in three regions of Cameroon.PloS one · 2013Article
- Variation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese.Genes and immunity · 2012Article
- High-throughput analysis of tumor necrosis factor signaling pathways in eight cell types during rat hepatic regeneration.Inflammation · 2012Article
- A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults.Malaria journal · 2010Article
- Risk for intentional violent death associated with HLA genotypes: a preliminary survey of deceased American organ donors.Genetica · 2009Article
- The evolution and diversity of TNF block haplotypes in European, Asian and Australian Aboriginal populations.Genes and immunity · 2009Article
- Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.The Journal of infectious diseases · 2009Article
- Article
- A TNF region haplotype offers protection from typhoid fever in Vietnamese patients.Human genetics · 2007Article
- Article
- Implications of inter-population linkage disequilibrium patterns on the approach to a disease association study in the human MHC class III.Immunogenetics · 2006Article
- How malaria has affected the human genome and what human genetics can teach us about malaria.American journal of human genetics · 2005Review
- TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study.Genes and immunity · 2004Article
- Is there a future for TNF promoter polymorphisms?Genes and immunity · 2004Review
- A systematic approach to the assessment of known TNF-alpha polymorphisms in Graves' disease.Genes and immunity · 2004Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TNF polymorphisms have been associated with susceptibility to malaria and other infectious and inflammatory conditions. We investigated a sample of 150 West African chromosomes to determine linkage disequilibrium (LD) between 25 SNP markers located in an 80 kb segment of the MHC Class III region encompassing TNF and eight neighbouring genes. We observed 45 haplotypes, and 22 of them comprise 80% of the sample. The pattern of LD is remarkably patchy, such that many markers show no LD with adjacent markers but high LD with markers that are much further away. We introduce a method of examining the implications of LD data for disease association studies based on sample size considerations: this shows that certain TNF polymorphisms would be likely to yield positive associations if the true disease allele resided in LTA or BAT1. We conclude that detailed marker maps are needed to resolve the causal origin of disease associations observed at the TNF locus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.