ArticlePlant physiology2003
SAGE analysis of transcriptome responses in Arabidopsis roots exposed to 2,4,6-trinitrotoluene.
Article in Plant physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 120 citations in OpenAlex.
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- Crucial Cell Signaling Compounds Crosstalk and Integrative Multi-Omics Techniques for Salinity Stress Tolerance in Plants.Frontiers in plant science · 2021Review
- Glyoxalase Goes Green: The Expanding Roles of Glyoxalase in Plants.International journal of molecular sciences · 2017Review
- Article
- Drosophila GSTs display outstanding catalytic efficiencies with the environmental pollutants 2,4,6-trinitrotoluene and 2,4-dinitrotoluene.Biochemistry and biophysics reports · 2016Article
- Plant transcriptomics and responses to environmental stress: an overview.Journal of genetics · 2015Review
- Phytodetoxification of the environmental pollutant and explosive 2,4,6-trinitrotoluene.Plant signaling & behavior · 2015Article
- Arabidopsis Glutathione Transferases U24 and U25 Exhibit a Range of Detoxification Activities with the Environmental Pollutant and Explosive, 2,4,6-Trinitrotoluene.Plant physiology · 2014Article
- Sequence and 3D structure based analysis of TNT degrading proteins in Arabidopsis thaliana.Journal of molecular modeling · 2014Article
- Physiological and transcriptional responses of Baccharis halimifolia to the explosive "composition B" (RDX/TNT) in amended soil.Environmental science and pollution research international · 2014Article
- Transcriptome sequencing and analysis of the fast growing shoots of moso bamboo (Phyllostachys edulis).PloS one · 2013Article
- Article
- Identification of condition-specific reference genes from microarray data for locusts exposed to hypobaric hypoxia.FEBS open bio · 2012Article
- Transferases and transporters mediate the detoxification and capacity to tolerate trinitrotoluene in Arabidopsis.Functional & integrative genomics · 2010Article
- Mammalian cytochrome CYP2E1 triggered differential gene regulation in response to trichloroethylene (TCE) in a transgenic poplar.Functional & integrative genomics · 2010Article
- From raw materials to validated system: the construction of a genomic library and microarray to interpret systemic perturbations in Northern bobwhite.Physiological genomics · 2010Article
- Detoxification without intoxication: herbicide safeners activate plant defense gene expression.Plant physiology · 2010Review
- Phytoremediation and phytosensing of chemical contaminants, RDX and TNT: identification of the required target genes.Functional & integrative genomics · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serial analysis of gene expression was used to profile transcript levels in Arabidopsis roots and assess their responses to 2,4,6-trinitrotoluene (TNT) exposure. SAGE libraries representing control and TNT-exposed seedling root transcripts were constructed, and each was sequenced to a depth of roughly 32,000 tags. More than 19,000 unique tags were identified overall. The second most highly induced tag (27-fold increase) represented a glutathione S-transferase. Cytochrome P450 enzymes, as well as an ABC transporter and a probable nitroreductase, were highly induced by TNT exposure. Analyses also revealed an oxidative stress response upon TNT exposure. Although some increases were anticipated in light of current models for xenobiotic metabolism in plants, evidence for unsuspected conjugation pathways was also noted. Identifying transcriptome-level responses to TNT exposure will better define the metabolic pathways plants use to detoxify this xenobiotic compound, which should help improve phytoremediation strategies directed at TNT and other nitroaromatic compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.