ArticleMolecular biology of the cell2003
Localization and dynamics of Cdc2-cyclin B during meiotic reinitiation in starfish oocytes.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Recycling of Uridylated mRNAs in Starfish Embryos.Biomolecules · 2024Article
- Crosstalk between mitotic reassembly and repair of the nuclear envelope.Nucleus (Austin, Tex.) · 2024Review
- Nuclear-cytoplasmic compartmentalization of cyclin B1-Cdk1 promotes robust timing of mitotic events.Cell reports · 2022Article
- SGK phosphorylates Cdc25 and Myt1 to trigger cyclin B-Cdk1 activation at the meiotic G2/M transition.The Journal of cell biology · 2019Article
- Effects of paclitaxel intervention on pulmonary vascular remodeling in rats with pulmonary hypertension.Experimental and therapeutic medicine · 2019Article
- A cdk1 gradient guides surface contraction waves in oocytes.Nature communications · 2017Article
- A novel class of cyclin-dependent kinase inhibitors identified by molecular docking act through a unique mechanism.The Journal of biological chemistry · 2009Article
- CDC2/SPDY transiently associates with endoplasmic reticulum exit sites during oocyte maturation.BMC developmental biology · 2009Article
- Distinct sequence elements of cyclin B1 promote localization to chromatin, centrosomes, and kinetochores during mitosis.Molecular biology of the cell · 2007Article
- A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown.Developmental cell · 2007Article
- Assembly of the cytokinetic contractile ring from a broad band of nodes in fission yeast.The Journal of cell biology · 2006Article
- Calcium at fertilization and in early development.Physiological reviews · 2006Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The Cdc2-cyclin B kinase has a central role in regulating the onset of M phase. In starfish oocytes, Cdc2-cyclin B begins to be activated approximately 10 min after application of maturation hormone, followed by accumulation in the nucleus then nuclear envelope breakdown. By immunofluorescence and by expressing a green fluorescent (GFP) chimera of cyclin B, we find that cyclin B is present in aggregates in the cytoplasm of immature oocytes. The aggregates disperse at approximately 10 min, suggesting that the dispersal is closely related to the activation of the kinase. Using cyclin B-GFP, the dispersion begins from the region containing the centrosomes. Extractability of Cdc2-cyclin B changes with similar kinetics during maturation. Active Cdc25 phosphatase released Cdc2-cyclin B from the detergent-insoluble fraction independently of its phosphatase activity. Live cell imaging also showed that Cdc2-cyclin B begins to accumulate in the nucleus before changes in nuclear pore permeability, consistent with Cdc2-cyclin B-induced disassembly of the pores.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.