Evidence map›Paper›PMID 1454523›Full record

ArticleNucleic acids research1992

Differential splicing creates a diversity of transcripts from a neurospecific developmentally regulated gene encoding a protein with new zinc-finger motifs.

V L Buchman, N N Ninkina, Y D Bogdanov, A L Bortvin, H N Akopian, S L Kiselev, Krylova OYu, K V Anokhin, G P Georgiev

Open access · greenAbstract read
In one paragraph

Article in Nucleic acids research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 30 citations in OpenAlex.

  1. TheInternational journal of molecular sciences · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Persyn, a member of the synuclein family, has a distinct pattern of expression in the developing nervous system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

V L BuchmanEngelhardt Institute of Molecular Biology, Moscow, Russia.
N N Ninkina
Y D Bogdanov
A L Bortvin
H N Akopian
S L Kiselev
Krylova OYu
K V Anokhin
G P Georgiev
Engelhardt Institute of Molecular Biology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have cloned a novel neurospecific gene, named neuro-d4, by differential screening a rat cerebral cortex cDNA library. Northern blot hybridization showed that neuro-d4 expression is restricted to neuronal tissues both in newborn and adult animals. The level of neuro-d4 mRNA in the rat central nervous system is high during the later stages of embryonic development and gradually decreases during the postnatal period. In situ hybridization suggests that the gene transcripts are localized in neuronal cell bodies. Nucleotide sequences of overlapped cDNA clones and all 12 exons in genomic clone were determined. The deduced protein has consensus sequences for a nuclear localization signal, a Krüppel-type zinc-finger and a new type of cysteine/histidine-rich motif resembling zinc-fingers. Several differential splicing variants were found, each of which influences the structure of the encoded protein.

Indexed as

Gene Expression RegulationRNA SplicingTranscription FactorsTranscription, GeneticAmino Acid SequenceAnimalsBase SequenceCerebral CortexDNAIn Situ HybridizationMolecular Sequence DataNerve Tissue ProteinsNeuronsOrgan SpecificityRatsRestriction MappingDNADpf1 protein, ratNerve Tissue ProteinsTranscription Factors

Identifiers

PMID1454523
PMCPMC334389
OpenAlexW1973570066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.