ReviewOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life1992
Experimental studies on the origin of the genetic code and the process of protein synthesis: a review update.
Review in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 59 citations in OpenAlex.
- Clustering single-cell multi-omics data via graph regularized multi-view ensemble learning.Bioinformatics (Oxford, England) · 2024Article
- Mixed Anhydride Intermediates in the Reaction of 5(4H)-Oxazolones with Phosphate Esters and Nucleotides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification.Life (Basel, Switzerland) · 2015Review
- Spontaneous Formation of RNA Strands, Peptidyl RNA, and Cofactors.Angewandte Chemie (International ed. in English) · 2015Article
- The origin of the genetic code: matter of metabolism or physicochemical determinism?Journal of molecular evolution · 2013Article
- Uniquely localized intra-molecular amino acid concentrations at the glycolytic enzyme catalytic/active centers of Archaea, Bacteria and Eukaryota are associated with their proposed temporal appearances on earth.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2013Article
- Article
- On the structural regularity in nucleobases and amino acids and relationship to the origin and evolution of the genetic code.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2005Article
- Artificially ambiguous genetic code confers growth yield advantage.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Guilt by association: the arginine case revisited.RNA (New York, N.Y.) · 2000Article
- The beta-sheets of proteins, the biosynthetic relationships between amino acids, and the origin of the genetic code.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1996Article
- The phylogeny of tRNAs seems to confirm the predictions of the coevolution theory of the origin of the genetic code.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1995Article
- Catalytic roles of the AMP at the 3' end of tRNAs.Molecular and cellular biochemistry · 1994Article
- The phylogeny of tRNA molecules and the origin of the genetic code.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1994Article
- The use of gel electrophoresis to study the reactions of activated amino acids with oligonucleotides.Journal of molecular evolution · 1994Article
- Couplings of character and of chirality in the origin of the genetic system.Journal of molecular evolution · 1993Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article is an update of our earlier review (Lacey and Mullins, 1983) in this journal on the origin of the genetic code and the process of protein synthesis. It is our intent to discuss only experimental evidence published since then although there is the necessity to mention the old enough to place the new in context. We do not include theoretical nor hypothetical treatments of the code or protein synthesis. Relevant data regarding the evolution of tRNAs and the recognition of tRNAs by aminoacyl-tRNA-synthetases are discussed. Our present belief is that the code arose based on a core of early assignments which were made on a physico-chemical and anticodonic basis and this was expanded with new assignments later. These late assignments do not necessarily show an amino acid-anticodon relatedness. In spite of the fact that most data suggest a code origin based on amino acid-anticodon relationships, some new data suggesting preferential binding of Arg to its codons are discussed. While information regarding coding is not increasing very rapidly, information regarding the basic chemistry of the process of protein synthesis has increased significantly, principally relating to aminoacylation of mono- and polyribonucleotides. Included in those studies are several which show stereoselective reactions of L-amino acids with nucleotides having D-sugars. Hydrophobic interactions definitely play a role in the preferences which have been observed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.