ArticleBMC bioinformatics2003
Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization.
Article in BMC bioinformatics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM.Communications biology · 2023Article
- Colchicine Blocks Tubulin Heterodimer Recycling by Tubulin Cofactors TBCA, TBCB, and TBCE.Frontiers in cell and developmental biology · 2021Article
- Nucleotide Binding to ARL2 in the TBCD∙ARL2∙β-Tubulin Complex Drives Conformational Changes in β-Tubulin.Journal of molecular biology · 2017Article
- TBCD may be a causal gene in progressive neurodegenerative encephalopathy with atypical infantile spinal muscular atrophy.Journal of human genetics · 2017Article
- Infantile neurodegenerative disorder associated with mutations in TBCD, an essential gene in the tubulin heterodimer assembly pathway.Human molecular genetics · 2016Article
- Biallelic Mutations in TBCD, Encoding the Tubulin Folding Cofactor D, Perturb Microtubule Dynamics and Cause Early-Onset Encephalopathy.American journal of human genetics · 2016Article
- Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major.Molecular and biochemical parasitology · 2015Article
- Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus.The Journal of biological chemistry · 2015Article
- The architecture of Trypanosoma brucei tubulin-binding cofactor B and implications for function.The FEBS journal · 2013Article
- The role of 26S proteasome-dependent proteolysis in the formation and restructuring of microtubule networks.Plant signaling & behavior · 2012Review
- The natural history of ubiquitin and ubiquitin-related domains.Frontiers in bioscience (Landmark edition) · 2012Review
- Faithful chaperones.Cellular and molecular life sciences : CMLS · 2011Review
- The solution structure of the N-terminal domain of human tubulin binding cofactor C reveals a platform for tubulin interaction.PloS one · 2011Article
- Diverse functions for the semaphorin receptor PlexinD1 in development and disease.Developmental biology · 2011Review
- The small GTPase ARL2 is required for cytokinesis in Trypanosoma brucei.Molecular and biochemical parasitology · 2010Article
- Tubulin chaperone E binds microtubules and proteasomes and protects against misfolded protein stress.Cellular and molecular life sciences : CMLS · 2010Article
- Tubulin heterodimers remain functional for one cell cycle after the inactivation of tubulin-folding cofactor D in fission yeast cells.Yeast (Chichester, England) · 2009Article
- PPARgamma Inhibitors as Novel Tubulin-Targeting Agents.PPAR research · 2008Article
- Systems analysis of chaperone networks in the malarial parasite Plasmodium falciparum.PLoS computational biology · 2007Article
- Small but versatile: the extraordinary functional and structural diversity of the beta-grasp fold.Biology direct · 2007Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe correct folding and dimerization of tubulins, before their addition to the microtubular structure, needs a group of conserved proteins called cofactors A to E. The biochemical analysis of cofactors gave an insight to their general functions, however not much is known about the domain structure and detailed, molecular function of these proteins.
resultsCombining modelling and fold prediction tools, we present 3D models of all cofactors, including several previously unannotated domains of cofactors B-E. Apart from the new HEAT and Armadillo domains in cofactor D and an unusual spectrin-like domain in cofactor C, we have identified a new subfamily of ubiquitin-like domains in cofactors B and E. Together, these observations provide a reliable, molecular level model of cofactor complex.
conclusionDistant homology searches allowed the identification of unknown regions of cofactors as self-reliant domains and allow us to present a detailed hypothesis of how a cofactor complex performs its function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.