ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Quantitative estimate of synaptic inputs to striatal neurons during up and down states in vitro.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- A dynamic computational model of the parallel circuit on the basal ganglia-cortex associated with Parkinson's disease dementia.Biological cybernetics · 2024Article
- Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons.Neuron · 2020Article
- Thinking Outside the Box (and Arrow): Current Themes in Striatal Dysfunction in Movement Disorders.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2019Review
- Article
- Differences in brain pathological changes between rotenone and 6-hydroxydopamine Parkinson's disease models.Neural regeneration research · 2018Article
- Detecting dopaminergic neuronal degeneration using diffusion tensor imaging in a rotenone-induced rat model of Parkinson's disease: fractional anisotropy and mean diffusivity values.Neural regeneration research · 2017Article
- Desynchronization of fast-spiking interneurons reduces β-band oscillations and imbalance in firing in the dopamine-depleted striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum.Journal of neurophysiology · 2014Article
- Lateral and feedforward inhibition suppress asynchronous activity in a large, biophysically-detailed computational model of the striatal network.Frontiers in computational neuroscience · 2014Article
- GABAergic circuits control spike-timing-dependent plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Dynamics of action potential firing in electrically connected striatal fast-spiking interneurons.Frontiers in cellular neuroscience · 2013Article
- Differential localization and function of GABA transporters, GAT-1 and GAT-3, in the rat globus pallidus.The European journal of neuroscience · 2011Article
- Spike-train communities: finding groups of similar spike trains.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The corticostriatal system in dissociated cell culture.Frontiers in systems neuroscience · 2011Article
- Striatal fast-spiking interneurons: from firing patterns to postsynaptic impact.Frontiers in systems neuroscience · 2011Article
- Exposure to cocaine dynamically regulates the intrinsic membrane excitability of nucleus accumbens neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Distinct roles of GABAergic interneurons in the regulation of striatal output pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Review
- Gap junctions between striatal fast-spiking interneurons regulate spiking activity and synchronization as a function of cortical activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Cortically activated interneurons shape spatial aspects of cortico-accumbens processing.Journal of neurophysiology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Up states are prolonged membrane potential depolarizations critical for synaptic integration and action potential generation in cortical and striatal neurons. They commonly result from numerous concurrent synaptic inputs, whereas neurons reside in a down state when synaptic inputs are few. By quantifying the composition, frequency, and amplitude of synaptic inputs for both states, we provide important constraints for state transitions in striatal network dynamics. Up and down states occur naturally in cortex-striatum-substantia nigra cocultures, which were used as an in vitro model in the present study. Spontaneous synaptic inputs during down states were extracted automatically in spiny projection neurons and fast spiking interneurons of the striatum using a newly developed computer algorithm. Consistent with a heterogeneous population of synaptic inputs, PSPs and PSCs showed no correlation in amplitude and rise time and occurred at relatively low frequencies of 10-40 Hz during the down state. The number of synaptic inputs during up states, estimated from the up-state charge and the unitary charge of down-state PSCs, was 217 +/- 44. Given the average up-state duration of 284 +/- 34 msec, synaptic input frequency was approximately 800 Hz during up-states for both neuronal types. Many down-state events reversed at the chloride reversal potential and were blocked by GABA(A) antagonists. The high correlation between up- and down-state reversal potential suggests that despite these drastic changes in synaptic input frequency, the ratio of inhibitory to excitatory currents is similar during both states.
Indexed as
Identifiers
14534246PMC6740825W2138574349What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.