ArticleJournal of clinical microbiology2003
emm typing of M nontypeable invasive group A streptococcal isolates in Israel.
Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Macrolide resistance in Streptococcus species.Journal of pharmacy & bioallied sciences · 2015Article
- Molecular epidemiology of sil locus in clinical Streptococcus pyogenes strains.Journal of clinical microbiology · 2014Article
- Characterization of sil in invasive group A and G streptococci: antibodies against bacterial pheromone peptide SilCR result in severe infection.Infection and immunity · 2013Article
- Molecular epidemiology of the sil streptococcal invasive locus in group A streptococci causing invasive infections in French children.Journal of clinical microbiology · 2007Article
- International quality assurance study for characterization of Streptococcus pyogenes.Journal of clinical microbiology · 2007Article
- A streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissues.The EMBO journal · 2006Article
- Bactericidal activity of M protein conserved region antibodies against group A streptococcal isolates from the Northern Thai population.BMC microbiology · 2006Article
- M protein gene (emm type) analysis of group A beta-hemolytic streptococci from Ethiopia reveals unique patterns.Journal of clinical microbiology · 2005Article
- Genetic diversity among type emm28 group A Streptococcus strains causing invasive infections and pharyngitis.Journal of clinical microbiology · 2005Article
- Streptococcal necrotising fasciitis from diverse strains of Streptococcus pyogenes in tropical northern Australia: case series and comparison with the literature.BMC infectious diseases · 2004Article
- Epidemiology and molecular characterization of Streptococcus pyogenes recovered from scarlet fever patients in central Taiwan from 1996 to 1999.Journal of clinical microbiology · 2004Article
- Genome-wide molecular dissection of serotype M3 group A Streptococcus strains causing two epidemics of invasive infections.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Group G streptococcal bacteremia in Jerusalem.Emerging infectious diseases · 2004Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed emm typing of M nontypeable invasive group A streptococcal (GAS) isolates collected in a prospective population-based study in Israel. One hundred twenty of 131 isolates (92%) had emm sequences compatible with GAS, consisting of 51 different emm types. Eleven isolates were found to be group G streptococcus. Of the 120 isolates, 55 (46%) belonged to 32 types for which there were no typing sera available in the Streptococcal Reference Laboratory in Israel. The other 65 (64%) isolates, consisting of 19 types, had sera available and therefore could have been serotyped. Forty-three isolates had T and emm types which were not correlated according to standard M-typing protocols and were therefore missed. The principal effect of emm typing was the addition of 32 types not previously identified in Israel and the discovery of new associations between emm and T types. emm typing did not significantly change the proportion of M types; the five most common types were 3, 28, 2, 62, and 41. Twenty different types comprised 80% of all isolates. No new emm sequences were discovered. emm typing emphasized the unusually low incidence of M1 strains causing severe disease in Israel. As serological typing of GAS becomes more problematic due to lack of sera and the appearance of new emm types, reference laboratories should replace M typing with emm sequence typing. Development of a GAS vaccine relies on the emm type distributions in different geographical locations. In our study, 7% of isolates (types 41 and 62) are not included in a 26-valent vaccine that is being studied.
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