ArticleJournal of clinical microbiology2003
Madurella mycetomatis strains from mycetoma lesions in Sudanese patients are clonal.
Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- The contribution of mycetoma grains to suboptimal disease management.Nature communications · 2025Review
- Genomics and metagenomics of Madurella mycetomatis, a causative agent of black grain mycetoma in Sudan.PLoS neglected tropical diseases · 2022Article
- A Short-Tandem-Repeat Assay (Journal of clinical microbiology · 2021Article
- The Accuracy of Histopathological and Cytopathological Techniques in the Identification of the Mycetoma Causative Agents.PLoS neglected tropical diseases · 2019Article
- Mycetoma laboratory diagnosis: Review article.PLoS neglected tropical diseases · 2017Review
- Pleurostomophora ochracea, a novel agent of human eumycetoma with yellow grains.Journal of clinical microbiology · 2012Article
- Negative pressure wound therapy and skin graft in madura foot treatment.Balkan medical journal · 2012Article
- Article
- Phenotypic and molecular characterization of Madurella pseudomycetomatis sp. nov., a novel opportunistic fungus possibly causing black-grain mycetoma.Journal of clinical microbiology · 2010Article
- Molecular identification of black-grain mycetoma agents.Journal of clinical microbiology · 2006Article
- Genotyping of Madurella mycetomatis by selective amplification of restriction fragments (amplified fragment length polymorphism) and subtype correlation with geographical origin and lesion size.Journal of clinical microbiology · 2005Article
- In vitro susceptibilities of Madurella mycetomatis to itraconazole and amphotericin B assessed by a modified NCCLS method and a viability-based 2,3-Bis(2-methoxy-4-nitro-5- sulfophenyl)-5-[(phenylamino)carbonyl]-2H-tetrazolium hydroxide (XTT) assay.Antimicrobial agents and chemotherapy · 2004Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular diversity among clinical isolates of Madurella mycetomatis, the prime fungal agent of human mycetoma in Sudan, could possibly explain the diverse clinical presentations of this severely debilitating infectious disease. In addition, culture-independent DNA-mediated typing tests need to be developed for this organism, since M. mycetomatis DNA, but not the organism itself, can be identified in soil, the material from which infections are thought to originate. A collection of 38 different clinical M. mycetomatis isolates was characterized by large-scale random amplification of polymorphic DNA using 20 different primer species. These analyses, involving at least 2,600 annealing sites, showed a complete lack of DNA fingerprint variation among the various isolates. From the resulting homogeneous DNA fingerprints, seven fragments were cloned and sequenced, and novel, species-specific PCR restriction fragment length polymorphism (RFLP) tests were designed. The seven PCR RFLP tests were successfully performed on the 38 different M. mycetomatis strains. However, again all M. mycetomatis DNA patterns obtained appeared to be identical, whereas patterns produced using DNAs from other fungal species were clearly discriminatory. These results suggest that there is little genetic variation among clinically relevant M. mycetomatis strains from Sudan. The data tentatively imply that different manifestations of mycetoma are due to differences in host susceptibility rather than differential virulence of the causative agent.
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