ReviewAnnals of the rheumatic diseases2003
Cartilage morphogenetic proteins: role in joint development, homoeostasis, and regeneration.
Review in Annals of the rheumatic diseases, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Material-Assisted Strategies for Osteochondral Defect Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Pooled it
- Nanotechnology-driven strategies for gene therapy of arthritis.Materials today. Bio · 2025Review
- Article
- Growth factor profile in calcified cartilage from the metaphysis of a calf costochondral junction, the site of initial bone formation.Biomedical reports · 2021Article
- Changes in DNA methylation accompany changes in gene expression during chondrocyte hypertrophic differentiation in vitro.Annals of the New York Academy of Sciences · 2021Article
- Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds.International journal of molecular sciences · 2020Review
- Cartilage Homeostasis Affects Femoral Head Necrosis Induced by Methylprednisolone in Broilers.International journal of molecular sciences · 2020Article
- Available Findings Fail to Provide Strong Evidence of the Role of Bone Morphogenic Protein-2 in Femoral Head Osteonecrosis.The archives of bone and joint surgery · 2020Review
- Cell therapy stimulates bone neoformation in calvaria defects in rats subjected to local irradiation.Animal models and experimental medicine · 2019Article
- Regulation of articular chondrocyte catabolic genes by growth factor interaction.Journal of cellular biochemistry · 2019Article
- Comparative Effectiveness of Structural versus Regulatory Protein Gene Transfer on Articular Chondrocyte Matrix Gene Expression.Cartilage · 2019Article
- Modulating cell response on cellulose surfaces; tunable attachment and scaffold mechanics.Cellulose (London, England) · 2018Article
- Treatment of stage II medication-related osteonecrosis of the jaw with necrosectomy and autologous bone marrow mesenchymal stem cells.Odontology · 2017Article
- Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2.The Journal of biological chemistry · 2017Article
- The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed.Molecules (Basel, Switzerland) · 2013Article
- Growth factor transgenes interactively regulate articular chondrocytes.Journal of cellular biochemistry · 2013Article
- Growth factor regulation of growth factor production by multiple gene transfer to chondrocytes.Growth factors (Chur, Switzerland) · 2013Article
- BMP-2 shows characteristic extracellular patterns in osteoarthritic cartilage: a preliminary report.GMS Interdisciplinary plastic and reconstructive surgery DGPW · 2013Article
- Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development.Histochemistry and cell biology · 2012Article
- Regulation of articular chondrocyte aggrecan and collagen gene expression by multiple growth factor gene transfer.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundArticular cartilage homoeostasis is critical for joint function. The steady state homoeostasis of articular cartilage is a balance between anabolic morphogens such as cartilage derived morphogenetic proteins (CDMPs) and bone morphogenetic proteins (BMPs) of the BMP family and catabolic cytokines such as interleukin (IL)1, IL17, and tumour necrosis factor alpha. Although bone and articular cartilage are adjacent tissues, there is a profound difference in their regeneration potential. Bone has the highest potential for regeneration. On the other hand, articular cartilage is recalcitrant to repair.
objectiveTo examine the hypothesis that the feeble innate regeneration ability of cartilage is due to the preponderance of catabolic cytokines such as IL1 and IL17.
resultsDuring a systematic investigation of CDMPs and cytokines IL17B (chondroleukin) was found in bovine articular cartilage. DISCUSSION AND
conclusionsBMP-7 and IL17B are present in articular cartilage and synthesised in chondrocytes as shown by northern blots and real-time reverse transcription-polymerase chain reaction. The coexistence of anabolic morphogens and catabolic cytokines in articular cartilage has important implications for cartilage homoeostasis and regeneration. The networks of signalling systems of morphogens and cytokines determine the net capacity for regenerative morphogenesis of articular cartilage. Finally, the feeble innate capacity for articular cartilage may be improved by targeted therapy by soluble receptors to block catabolic cytokines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.