ArticleThe EMBO journal2003
Distinct regulators for Plk1 activation in starfish meiotic and early embryonic cycles.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Selective dephosphorylation by PP2A-B55 directs the meiosis I-meiosis II transition in oocytes.eLife · 2021Article
- Centriole foci persist in starfish oocytes despite Polo-like kinase 1 inactivation or loss of microtubule nucleation activity.Molecular biology of the cell · 2020Article
- SGK phosphorylates Cdc25 and Myt1 to trigger cyclin B-Cdk1 activation at the meiotic G2/M transition.The Journal of cell biology · 2019Article
- Specialization of CDK1 and cyclin B paralog functions in a coenocystic mode of oogenic meiosis.Cell cycle (Georgetown, Tex.) · 2018Article
- MPF-based meiotic cell cycle control: Half a century of lessons from starfish oocytes.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Review
- Plk1 inhibition leads to a failure of mitotic division during the first mitotic division in pig embryos.Journal of assisted reproduction and genetics · 2017Article
- Entry into mitosis: a solution to the decades-long enigma of MPF.Chromosoma · 2015Review
- Preclinical Childhood Sarcoma Models: Drug Efficacy Biomarker Identification and Validation.Frontiers in oncology · 2015Review
- Functional specialization of chordate CDK1 paralogs during oogenic meiosis.Cell cycle (Georgetown, Tex.) · 2015Article
- Cyclin B-Cdk1 inhibits protein phosphatase PP2A-B55 via a Greatwall kinase-independent mechanism.The Journal of cell biology · 2014Article
- Antisense morpholino targeting just upstream from a poly(A) tail junction of maternal mRNA removes the tail and inhibits translation.Nucleic acids research · 2012Article
- Regulation of inositol 1,4,5-trisphosphate receptor function during mouse oocyte maturation.Journal of cellular physiology · 2012Article
- Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factor.Nature communications · 2012Article
- Female infertility in PDE3A(-/-) mice: polo-like kinase 1 (Plk1) may be a target of protein kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A(-/-) mice.Cell cycle (Georgetown, Tex.) · 2010Article
- The Plk1 inhibitor BI 2536 temporarily arrests primary cardiac fibroblasts in mitosis and generates aneuploidy in vitro.PloS one · 2010Article
- Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs.Developmental biology · 2008Article
- Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Crystallization and preliminary X-ray diffraction studies on the human Plk1 Polo-box domain in complex with an unphosphorylated and a phosphorylated target peptide from Cdc25C.Acta crystallographica. Section F, Structural biology and crystallization communications · 2006Article
- CCT chaperonin complex is required for the biogenesis of functional Plk1.Molecular and cellular biology · 2005Article
- The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs.The EMBO journal · 2005Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Polo-like kinase, Plk, has multiple roles in regulating mitosis. In particular, Plk1 has been postulated to function as a trigger kinase that phosphorylates and activates Cdc25C prior to the activation of cyclin B-Cdc2 and thereby initiates its activation. However, the upstream regulation of Plk1 activation remains unclear. Here we have studied the interplay between Plk1 and Cdc2 through meiotic and early embryonic cycles in starfish. Distinct kinases, cyclin B-Cdc2, MAPK along with cyclin B- and/or cyclin A-Cdc2 and cyclin A-Cdc2, were unique upstream regulators for Plk1 activation at meiosis I, meiosis II and embryonic M-phase, respectively, indicating that Plk1 is not the trigger kinase at meiotic reinitiation. When Plk1 was required for cyclin B-Cdc2 activation, the action of Plk1 was mediated primarily through suppression of Myt1 rather than through activation of Cdc25. We propose that Plk1 can be activated by either cyclin A- or cyclin B-Cdc2, and its primary target is Myt1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.