ArticleThe EMBO journal2003
Dmp53 protects the Drosophila retina during a developmentally regulated DNA damage response.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Systematic analysis of noncanonical ribosomal protein paralogs does not provide evidence for specialized functions inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Protein expression of nucleolar protein 12 in the retina and its implication in protection of retina from UV irradiation damage.Cell death discovery · 2024Article
- Adaptive homeostasis and the p53 isoform network.EMBO reports · 2021Review
- Dpp/TGFβ-superfamily play a dual conserved role in mediating the damage response in the retina.PloS one · 2021Article
- DNA Damaged Induced Cell Death in Oocytes.Molecules (Basel, Switzerland) · 2020Review
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- p53 Isoforms: Key Regulators of the Cell Fate Decision.Cold Spring Harbor perspectives in medicine · 2016Review
- Immune modulation by MANF promotes tissue repair and regenerative success in the retina.Science (New York, N.Y.) · 2016Article
- The Stress-responsive Gene ATF3 Mediates Dichotomous UV Responses by Regulating the Tip60 and p53 Proteins.The Journal of biological chemistry · 2016Article
- The p53 control of apoptosis and proliferation: lessons from Drosophila.Apoptosis : an international journal on programmed cell death · 2014Review
- Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome.Cancer letters · 2014Article
- Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation.Cell death and differentiation · 2013Article
- p53 binding prevents phosphatase-mediated inactivation of diphosphorylated c-Jun N-terminal kinase.The Journal of biological chemistry · 2012Article
- Schnurri regulates hemocyte function to promote tissue recovery after DNA damage.Journal of cell science · 2012Article
- mir-11 limits the proapoptotic function of its host gene, dE2f1.Genes & development · 2011Article
- Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage.Developmental cell · 2011Article
- Phylogeny and function of the invertebrate p53 superfamily.Cold Spring Harbor perspectives in biology · 2010Review
- Article
- Regulation of Drosophila melanogaster pro-apoptotic gene hid.Apoptosis : an international journal on programmed cell death · 2009Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Ultraviolet (UV) light is absorbed by cellular proteins and DNA, promoting skin damage, aging and cancer. In this paper, we explore the UV response by cells of the Drosophila retina. We demonstrate that the retina enters a period of heightened UV sensitivity in the young developing pupa, a stage closely associated with its period of normal developmental programmed cell death. Injury to irradiated cells included morphology changes and apoptotic cell death; these defects could be completely accounted for by DNA damage. Cell death, but not morphological changes, was blocked by the caspase inhibitor P35. Utilizing genetic and microarray data, we provide evidence for the central role of Hid expression and for Diap1 protein stability in controlling the UV response. In contrast, we found that Reaper had no effect on UV sensitivity. Surprisingly, Dmp53 is required to protect cells from UV-mediated cell death, an effect attributed to its role in DNA repair. These in vivo results demonstrate that the cellular effects of DNA damage depend on the developmental status of the tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.