ReviewCurrent rheumatology reports2003
Recent advances in understanding molecular mechanisms in the pathogenesis and antibody profile of Sjögren's syndrome.
Review in Current rheumatology reports, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03765593 (Gene Expression of Interferon), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gene Expression of Interferon (INF) and B Lymphocyte Biomarkers as Markers of Systemic Affectation and Lymphoproliferative Disease in Primary Sjögren's Syndrome
Who cites it
16 citing papers in PubMed, 53 citations in OpenAlex.
- Microbiome-based therapeutics for ocular diseases.Clinical & experimental optometry · 2025Review
- Fluorescence-based reagent and spectrum-based optical reader for lactoferrin detection in tears: differentiating Sjögren's syndrome from non-Sjögren's dry eye syndrome.Scientific reports · 2024Article
- Primary Immune Responses and Affinity Maturation Are Controlled by IgD.Frontiers in immunology · 2021Article
- Plant-Derived Chimeric Virus Particles for the Diagnosis of Primary Sjögren Syndrome.Frontiers in plant science · 2015Article
- TACI-Fc gene therapy improves autoimmune sialadenitis but not salivary gland function in non-obese diabetic mice.Oral diseases · 2012Article
- Vasculitis in Sjögren's Syndrome.Current rheumatology reports · 2011Review
- Pathogenetic mechanisms in the initiation and perpetuation of Sjögren's syndrome.Nature reviews. Rheumatology · 2010Review
- EGF activates PI3K-Akt and NF-kappaB via distinct pathways in salivary epithelial cells in Sjögren's syndrome.Rheumatology international · 2007Article
- Quantitative salivary gland scintigraphy can distinguish patients with primary Sjøgren's syndrome during the evaluation of sicca symptoms.Clinical rheumatology · 2007Article
- A conspicuous role for B cells In Sjögren's syndrome.Clinical reviews in allergy & immunology · 2007Review
- Decreased B cell activating factor receptor expression on peripheral lymphocytes associated with increased disease activity in primary Sjögren's syndrome and systemic lupus erythematosus.Annals of the rheumatic diseases · 2007Article
- Serum immunoglobulin free light chain assessment in rheumatoid arthritis and primary Sjogren's syndrome.Annals of the rheumatic diseases · 2007Article
- Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren's syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndrome.Arthritis research & therapy · 2006Article
- Correlation of serum B lymphocyte stimulator and beta2 microglobulin with autoantibody secretion and systemic involvement in primary Sjogren's syndrome.Annals of the rheumatic diseases · 2005Article
- Association between circulating levels of the novel TNF family members APRIL and BAFF and lymphoid organization in primary Sjögren's syndrome.Journal of clinical immunology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sjögren's syndrome is a chronic autoimmune and rheumatic disorder of the mucous membranes caused by a lack of proper exocrine secretions, with prominent sicca complaints. The molecular mechanisms of the pathogenesis are virtually unknown, although progress has been made with regard to chemokines, B cell activating factor, and apoptosis. A large number of autoantibodies have been reported in Sjögren's syndrome, some of which relate to impairment of glandular function. Sjögren's syndrome is a female-dominant disease with a late age of onset; most patients contract the disease at the age of 40 to 50 years. Lately, attention has been drawn to the effects of adrenopause in Sjögren's syndrome and on dehydroepiandrosterone and its intracrine metabolism in target tissues. This can influence the maintenance and remodeling of exocrine glands and may explain, in part, another important disease symptom--fatigue.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.