ArticleImmunogenetics2003
Evolution of the proto-MHC ancestral region: more evidence for the plesiomorphic organisation of human chromosome 9q34 region.
Article in Immunogenetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Insights into cephalochordate genome and gene evolution from the early-diverging amphioxusProceedings of the National Academy of Sciences of the United States of America · 2026Article
- γδ T, NKT, and MAIT Cells During Evolution: Redundancy or Specialized Functions?Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- Towards the elements of successful insect RNAi.Journal of insect physiology · 2013Review
- R4 regulators of G protein signaling (RGS) identify an ancient MHC-linked synteny group.Immunogenetics · 2013Article
- Immune related genes underpin the evolution of adaptive immunity in jawless vertebrates.Current genomics · 2012Article
- Dissecting systemic RNA interference in the red flour beetle Tribolium castaneum: parameters affecting the efficiency of RNAi.PloS one · 2012Article
- Origin and evolution of the adaptive immune system: genetic events and selective pressures.Nature reviews. Genetics · 2010Review
- CASSIOPE: an expert system for conserved regions searches.BMC bioinformatics · 2009Article
- Exploring systemic RNA interference in insects: a genome-wide survey for RNAi genes in Tribolium.Genome biology · 2008Article
- Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system.Genome research · 2007Article
- The genomic environment around the Aromatase gene: evolutionary insights.BMC evolutionary biology · 2005Article
- FIGENIX: intelligent automation of genomic annotation: expertise integration in a new software platform.BMC bioinformatics · 2005Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present day structure of the vertebrate major histocompatibility complex (MHC) and its three paralogous regions has always been a focus of interest. In a recent study, nine human anchor genes located in the MHC region were cloned from a Branchiostoma floridae (amphioxus) cosmid library. The identification and analysis of 31 surrounding genes led to the most probable model of two rounds of en bloc duplication giving rise to these regions. These events were estimated to have occurred after the cephalochordata-craniata divergence [approximately 766 million years ago (Mya)] and before the Gnathostomata radiation (approximately 528 Mya). Furthermore, it was also shown that after this large-scale duplication one of these regions, corresponding to the human 9q33-q34, had retained an ancestral organisation. In the present study, four new cosmids in the amphioxus proto-MHC region were identified by the chromosomal walking technique. These cosmids were sequenced, and their structural annotation was performed, leading to the prediction of eleven genes. Their phylogenetic relationships among species corroborate the results obtained previously and provide more evidence for the plesiomorphic state of the human chromosome 9q33-34 MHC paralogous region.
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