ArticleProceedings of the National Academy of Sciences of the United States of America2003
Inhibition of NF-kappaB by ZAS3, a zinc-finger protein that also binds to the kappaB motif.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Identification and characterization of extrachromosomal circular DNA in large-artery atherosclerotic stroke.Journal of cellular and molecular medicine · 2024Article
- Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2.Cell death & disease · 2023Article
- Schnurri 3 promotes Th2 cytokine production during the late phase of T-cell antigen stimulation.European journal of immunology · 2022Article
- Monocyte biology conserved across species: Functional insights from cattle.Frontiers in immunology · 2022Article
- Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells.Nature communications · 2020Article
- NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB.Cancers · 2019Review
- NovelMolecular syndromology · 2019Article
- Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells.Oncotarget · 2017Article
- Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells.Circulation research · 2013Article
- Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus.Molecular immunology · 2013Article
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- Zinc in innate and adaptive tumor immunity.Journal of translational medicine · 2010Review
- Targeting activation-induced cytidine deaminase overcomes tumor evasion of immunotherapy by CTLs.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
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- NF-kappaB regulation: the nuclear response.Journal of cellular and molecular medicine · 2009Review
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- Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development.Gene expression · 2007Article
- Reciprocal regulation of nuclear factor kappa B and its inhibitor ZAS3 after peripheral nerve injury.BMC neuroscience · 2006Article
- Regulation of T helper type 2 cell differentiation by murine Schnurri-2.The Journal of experimental medicine · 2005Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ZAS proteins are large zinc-finger transcriptional proteins implicated in growth, signal transduction, and lymphoid development. Recombinant ZAS fusion proteins containing one of the two DNA-binding domains have been shown to bind specifically to the kappaB motif, but the endogenous ZAS proteins or their physiological functions are largely unknown. The kappaB motif, GGGACTTTCC, is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth. The Rel family of NF-kappaB, predominantly p65.p50 and p50.p50, are transcription factors well known for inducing gene expression by means of interaction with the kappaB motif during acute-phase responses. A functional link between ZAS and NF-kappaB, two distinct families of kappaB-binding proteins, stems from our previous in vitro studies that show that a representative member, ZAS3, associates with TRAF2, an adaptor molecule in tumor necrosis factor signaling, to inhibit NF-kappaB activation. Biochemical and genetic evidence presented herein shows that ZAS3 encodes major kappaB-binding proteins in B lymphocytes, and that NF-kappaB is constitutively activated in ZAS3-deficient B cells. The data suggest that ZAS3 plays crucial functions in maintaining cellular homeostasis, at least in part by inhibiting NF-kappaB by means of three mechanisms: inhibition of nuclear translocation of p65, competition for kappaB gene regulatory elements, and repression of target gene transcription.
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