ReviewOncogene2003
Emerging roles of DNA tumor viruses in cell proliferation: new insights into genomic instability.
Review in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03325517 (Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics
Who cites it
26 citing papers in PubMed, 73 citations in OpenAlex.
- Oncoviruses at the Crossroads of Ageing and Cancer: Molecular Mechanisms and Key Signalling Pathways.Reviews in medical virology · 2026Review
- Virus-induced host genomic remodeling dysregulates gene expression, triggering tumorigenesis.Frontiers in cellular and infection microbiology · 2024Review
- The GTPase RAN regulates multiple steps of the centrosome life cycle.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Article
- Article
- Cell cycle regulation during viral infection.Methods in molecular biology (Clifton, N.J.) · 2014Review
- Molecular mechanisms of natural killer cell activation in response to cellular stress.Cell death and differentiation · 2014Review
- RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry.The Journal of experimental medicine · 2012Article
- Human papillomavirus-16 E7 interacts with glutathione S-transferase P1 and enhances its role in cell survival.PloS one · 2009Article
- The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle.PloS one · 2009Article
- Viral manipulation of DNA repair and cell cycle checkpoints.DNA repair · 2009Review
- Article
- Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.The EMBO journal · 2009Article
- Transactivator IE1 is required for baculovirus early replication events that trigger apoptosis in permissive and nonpermissive cells.Journal of virology · 2009Article
- PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigen.Oncogene · 2008Article
- Inhibition of apoptosis in Cryptosporidium parvum-infected intestinal epithelial cells is dependent on survivin.Infection and immunity · 2008Article
- Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.PLoS pathogens · 2007Article
- Epstein-Barr virus thymidine kinase is a centrosomal resident precisely localized to the periphery of centrioles.Journal of virology · 2007Article
- Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways.The EMBO journal · 2006Article
- Review
- Cell type-specific role of the retinoblastoma/E2F pathway during Arabidopsis leaf development.Plant physiology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The small DNA virus proteins E1A and E1B from human Adenovirus, E6 and E7 from human papillomavirus, and large T and small T antigens from SV40, are multifaceted molecular tools that can carry out an impressive number of tasks in the host cell. These viral factors, collectively termed 'oncoproteins' for their ability to induce cancer, can be viewed as paradigmatic oncogenic factors which can disrupt checkpoint controls at multiple levels--they interfere with both 'gatekeeper' cellular functions, including major control pathways of cell cycle and apoptosis, and with 'caretaker' functions, thereby inducing mitotic abnormalities and increasing genomic instability. Both E1A and E7 have been recently found to interact physically with the Ran GTPase. This interaction is key in uncoupling the centrosome cycle from the cell cycle, highlighting a direct link between viral infection and the induction of genomic instability. Further expanding our current knowledge in this field will be crucial to elucidate viral strategies leading to cellular transformation and cancer progression, as well as design novel preventive or therapeutic approaches to human cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.