ReviewNeuromolecular medicine2003
Making yeast tremble: yeast models as tools to study neurodegenerative disorders.
Review in Neuromolecular medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- iPSC-Derived 3D Brain Organoids as Next-generation Platforms to Study Viral and Toxicant-associated Neurodegeneration.Stem cell reviews and reports · 2026Review
- Modeling of Neurodegenerative Diseases: 'Step by Step' and 'Network' Organization of the Complexes of Model Systems.International journal of molecular sciences · 2022Review
- Huntingtin Polyglutamine Fragments Are a Substrate for Hsp104 in Saccharomyces cerevisiae.Molecular and cellular biology · 2021Article
- ExploringMicrobial cell (Graz, Austria) · 2021Review
- Uncoupling the Trade-Off between Somatic Proteostasis and Reproduction inFrontiers in molecular neuroscience · 2017Article
- Experimental models for identifying modifiers of polyglutamine-induced aggregation and neurodegeneration.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2013Article
- FSRD: fungal stress response database.Database : the journal of biological databases and curation · 2013Article
- Article
- Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex.PloS one · 2012Article
- Ordered assembly of heat shock proteins, Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes.The Journal of biological chemistry · 2011Article
- Article
- Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- pdf1, a palmitoyl protein thioesterase 1 Ortholog in Schizosaccharomyces pombe: a yeast model of infantile Batten disease.Eukaryotic cell · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic experiments in mice, which are indispensable for studying the molecular basis of neurological disorders, have certain limitations that include slow pace and high costs. It is therefore not surprising that in recent years numerous neurological diseases have been modeled in genetically tractable organisms, including Drosophila, Caenorhabditis elegans, and yeast. Yeast models in particular have a special advantage with respect to genome-wide experimental approaches as a result of the completed sequencing of the genome, the availability of a collection of precise deletion mutants of every gene in the genome, and the rapidly evolving databases of yeast protein-protein interactions and gene expression patterns. These large and easily accessible bodies of information, coupled with the ease with which yeast can be manipulated genetically, have led to dissection of novel mechanisms of neurodegenerative disorders. In this review, we discuss how studies in yeast models have already resulted in significant insights into the understanding of neurodegenerative disorders that include prion disease, Parkinson's disease, polyglutamine expansion disorders, Friedreich's ataxia, and Batten disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.