ReviewNeuromolecular medicine2003
Tau protein in familial and sporadic diseases.
Review in Neuromolecular medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Single cell RNA sequencing and emerging transcriptomic technologies in Alzheimer's disease cerebral organoids: a mini review.Molecular brain · 2026Review
- Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes.Nature communications · 2017Article
- Frontotemporal dementia-related gene mutations in clinical dementia patients from a Chinese population.Journal of human genetics · 2016Article
- Neuronal degeneration, synaptic defects, and behavioral abnormalities in tau₄₅₋₂₃₀ transgenic mice.Neuroscience · 2014Article
- Frontotemporal lobar degeneration: current knowledge and future challenges.Journal of neurology · 2012Review
- Clinical phenotypes and genetic biomarkers of FTLD.Journal of neural transmission (Vienna, Austria : 1996) · 2012Review
- Tau and tauopathies.Progress in molecular biology and translational science · 2012Review
- Genetics of frontotemporal lobar degeneration.Frontiers in neurology · 2012Article
- Morin attenuates tau hyperphosphorylation by inhibiting GSK3β.Neurobiology of disease · 2011Article
- Mice with mutation in dynein heavy chain 1 do not share the same tau expression pattern with mice with SOD1-related motor neuron disease.Neurochemical research · 2011Article
- Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies.Molecular medicine (Cambridge, Mass.) · 2011Article
- Gene organization, evolution and expression of the microtubule-associated protein ASAP (MAP9).BMC genomics · 2008Article
- Neuronal hypertrophy in asymptomatic Alzheimer disease.Journal of neuropathology and experimental neurology · 2008Article
- Interaction of tau protein with the dynactin complex.The EMBO journal · 2007Article
- Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target.Journal of biomedicine & biotechnology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal protein aggregation is a common characteristic of many neurodegenerative diseases of the brain. Filamentous deposits made of the microtubule-associated protein tau constitute a major defining characteristic of several neurodegenerative diseases known as tauopathies. The role of tau in neurodegeneration has been clarified by the identification of genetic mutations in the tau gene in cases with familial frontotemporal dementia and parkinsonism linked to chromosome 17. Furthermore, some sporadic tauopathies are associated with tau gene polymorphisms. Although it is still debated how tau gene mutations lead to neuronal death, it is clear that different mutations lead to tau pathologies with characteristics similar to those found in sporadic tauopathies. These findings have definitely shown that in tauopathies tau aggregation is directly associated with development of neurodegeneration and neuronal death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.