ArticleProceedings of the National Academy of Sciences of the United States of America2003
Protective immunity against Helicobacter is characterized by a unique transcriptional signature.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 62 citations in OpenAlex.
- Gene expression patterns induced by HPV-16 L1 virus-like particles in leukocytes from vaccine recipients.Journal of immunology (Baltimore, Md. : 1950) · 2009Trial
- Trial
- Leptin, CD4(+) T(reg) and the prospects for vaccination against H. pylori infection.Frontiers in immunology · 2012Article
- Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines.PLoS neglected tropical diseases · 2010Article
- Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell.BMC genomics · 2009Article
- Helicobacter pylori and Gastric Mucosa-associated Lymphoid Tissue (MALT) Lymphoma: Updated Review of Clinical Outcomes and the Molecular Pathogenesis.Gut and liver · 2009Article
- Identification of novel cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo.Molecular cancer · 2009Article
- Fatty acid composition of subcutaneous adipose tissue and gastric mucosa: is there a relation with gastric ulceration?BMC gastroenterology · 2009Article
- Liver transcriptome profiles associated with strain-specific Ehrlichia chaffeensis-induced hepatitis in SCID mice.Infection and immunity · 2009Article
- Decreased body fat and gastric cancer: does the hen come before the egg, or vice versa?Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2008Article
- Gene expression profiles of Chlamydophila pneumoniae during the developmental cycle and iron depletion-mediated persistence.PLoS pathogens · 2007Article
- Visualization of three-way comparisons of omics data.BMC bioinformatics · 2007Article
- The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of helicobacter-induced mucosa-associated lymphoid tissue lymphoma.The American journal of pathology · 2005Article
- Identification of novel genes in intestinal tissue that are regulated after infection with an intestinal nematode parasite.Infection and immunity · 2005Article
- Insights into host responses against pathogens from transcriptional profiling.Nature reviews. Microbiology · 2005Review
- From Pasteur to genomics: progress and challenges in infectious diseases.Nature medicine · 2004Article
- Delineation of upstream signaling events in the salmonella pathogenicity island 2 transcriptional activation pathway.Journal of bacteriology · 2004Article
- Helicobacter pylori persistence: biology and disease.The Journal of clinical investigation · 2004Review
- Resistin levels are normal in hypothyroidism and remain unchanged after attainment of euthyroidism: relationship with insulin levels and anthropometric parameters.Journal of endocrinological investigationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Immunization with a whole-cell sonicate vaccine of Helicobacter felis in conjunction with cholera toxin as a mucosal adjuvant induces long-term protective immunity in a majority of laboratory mice. We have combined gene expression profiling and immunohistochemical analysis on a set of immunized animals to better understand the mechanism of protection. The stomachs of protected animals exhibited a strikingly different transcriptional profile compared with those of nonprotected or control mice, indicating that vaccination targets the appropriate site and leaves a molecular signature. Among the genes whose up-regulation is significantly correlated with protection are a number of adipocyte-specific factors. These include the fat-cell-specific cytokines adipsin, resistin, and adiponectin and the adipocyte surface marker CD36. Interestingly, potentially protective T and B lymphocytes can be found embedded in the adipose tissue surrounding protected stomachs but never in control or unprotected stomachs. Adipsin-specific immunohistochemical staining of protected stomach sections further revealed molecular cross-talk between adjacent lymphoid and adipose cell populations. We propose a mechanism of protection that involves the effector responses of either or both lymphocyte subclasses as well as the previously unappreciated paracrine functions of adipose tissue surrounding the resident lymphocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.