ArticleAmerican journal of respiratory cell and molecular biology2004
Resident murine alveolar and peritoneal macrophages differ in adhesion of apoptotic thymocytes.
Article in American journal of respiratory cell and molecular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- MERTK coordinates efferocytosis by regulating integrin localization and activation.Journal of cell science · 2026Article
- Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development.International journal of molecular sciences · 2020Article
- Review
- Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation.JCI insight · 2020Article
- Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors.ACS medicinal chemistry letters · 2016Article
- MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Tyro3, Axl, and Mertk receptor signaling in inflammatory bowel disease and colitis-associated cancer.Inflammatory bowel diseases · 2014Review
- Glucocorticoids relieve collectin-driven suppression of apoptotic cell uptake in murine alveolar macrophages through downregulation of SIRPα.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Expression and preliminary functional analysis of Siglec-F on mouse macrophages.Journal of Zhejiang University. Science. B · 2012Article
- Article
- Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling.The Journal of experimental medicine · 2009Article
- Tyro3 receptor tyrosine kinases in the heterogeneity of apoptotic cell uptake.Frontiers in bioscience (Landmark edition) · 2009Review
- Overexpression of apoptotic cell removal receptor MERTK in alveolar macrophages of cigarette smokers.American journal of respiratory cell and molecular biology · 2008Article
- Surfactant protein D inhibits TNF-alpha production by macrophages and dendritic cells in mice.The Journal of allergy and clinical immunology · 2008Article
- The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages.Journal of leukocyte biology · 2008Article
- TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer.Advances in cancer research · 2008Review
- Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells.Blood · 2007Article
- Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation.Respiratory research · 2005Article
- Monocytes recruited to the lungs of mice during immune inflammation ingest apoptotic cells poorly.American journal of respiratory cell and molecular biology · 2005Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Apoptotic cells must be cleared efficiently by macrophages (Mø) to prevent autoimmunity, yet their ingestion impairs Mø microbicidal function. The principal murine resident lung phagocyte, the alveolar Mø (AMø), is specifically deficient at apoptotic cell ingestion, both in vitro and in vivo, compared with resident peritoneal Mø (PMø). To further characterize this deficiency, we assayed static adhesion in vitro using apoptotic thymocytes and resident AMø and PMø from normal C57BL/6 mice. Adhesion of apoptotic thymocytes by both types of Mø was rapid, specific, and cold-sensitive. Antibody against the receptor tyrosine kinase MerTK (Tyro12) blocked phagocytosis but not adhesion in both types of Mø. Surfactant protein A increased adhesion and phagocytosis by AMø, but not to the levels seen using PMø. Adhesion was largely cation-independent for PMø and calcium-dependent for AMø. Adhesion was not inhibited in either Mø type by mAbs against beta1 or beta3 integrins or scavenger receptor I/II (CD204), but AMø adhesion was inhibited by specific mAbs against CD11c/CD18. Thus, resident murine tissue Mø from different tissues depend on qualitatively disparate receptor systems to bind apoptotic cells. The decreased capacity of murine AMø to ingest apoptotic cells is only partially explained by reduced initial adhesion.
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