ArticleJournal of bacteriology2003
Regulation of expression of the 2-deoxy-D-ribose utilization regulon, deoQKPX, from Salmonella enterica serovar typhimurium.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- A validated pangenome-scale metabolic model for theMicrobial genomics · 2024Article
- Unveiling the fructose metabolism system in Staphylococcus aureus: insights into the regulatory role of FruR and the FruRKT operon in bacterial fitness.BMC microbiology · 2024Article
- Genomic Insights Into the Interspecific Diversity and Evolution ofFrontiers in microbiology · 2022Article
- Developing Wound Dressings Using 2-deoxy-International journal of molecular sciences · 2021Review
- Development of a Genome-Scale Metabolic Model and Phenome Analysis of the ProbioticInternational journal of molecular sciences · 2021Article
- Identification of a Novel L-rhamnose Uptake Transporter in the Filamentous Fungus Aspergillus niger.PLoS genetics · 2016Article
- Genome sequence of a food spoilage lactic acid bacterium, Leuconostoc gasicomitatum LMG 18811T, in association with specific spoilage reactions.Applied and environmental microbiology · 2011Article
- Article
- Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042.PloS one · 2010Article
- Genome scale reconstruction of a Salmonella metabolic model: comparison of similarity and differences with a commensal Escherichia coli strain.The Journal of biological chemistry · 2009Article
- Role of deoxyribose catabolism in colonization of the murine intestine by pathogenic Escherichia coli strains.Infection and immunity · 2009Article
- The DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate:sugar phosphotransferase system (PTS) in Corynebacterium glutamicum.BMC molecular biology · 2007Article
- Deciphering the function of an ORF: Salmonella enterica DeoM protein is a new mutarotase specific for deoxyribose.Protein science : a publication of the Protein Society · 2004Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella enterica, in contrast to Escherichia coli K12, can use 2-deoxy-D-ribose as the sole carbon source. The genetic determinants for this capacity in S. enterica serovar Typhimurium include four genes, of which three, deoK, deoP, and deoX, constitute an operon. The fourth, deoQ, is transcribed in the opposite direction. The deoK gene encodes deoxyribokinase. In silico analyses indicated that deoP encodes a permease and deoQ encodes a regulatory protein of the deoR family. The deoX gene product showed no match to known proteins in the databases. Deletion analyses showed that both a functional deoP gene and a functional deoX gene were required for optimal utilization of deoxyribose. Using gene fusion technology, we observed that deoQ and the deoKPX operon were transcribed from divergent promoters located in the 324-bp intercistronic region between deoQ and deoK. The deoKPX promoter was 10-fold stronger than the deoQ promoter, and expression was negatively regulated by DeoQ as well as by DeoR, the repressor of the deoxynucleoside catabolism operon. Transcription of deoKPX but not of deoQ was regulated by catabolite repression. Primer extension analysis identified the transcriptional start points of both promoters and showed that induction by deoxyribose occurred at the level of transcription initiation. Gel retardation experiments with purified DeoQ illustrated that it binds independently to tandem operator sites within the deoQ and deoK promoter regions with K(d) values of 54 and 2.4 nM, respectively.
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