ArticleGenome research2003
Extensive exon reshuffling over evolutionary time coupled to trans-splicing in Drosophila.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Promoter Specificity and Transcription Levels ModulateInternational journal of molecular sciences · 2025Article
- An Investigation of the Conservatism of Sequences Defining trans-Splicing in the mod(mdg4) Locus across Drosophila and Silkworm Species.Doklady. Biochemistry and biophysics · 2025Article
- Emergence and influence of sequence bias in evolutionarily malleable, mammalian tandem arrays.BMC biology · 2023Article
- Evolutionary honing in and mutational replacement: how long-term directed mutational responses to specific environmental pressures are possible.Theory in biosciences = Theorie in den Biowissenschaften · 2023Review
- Conserved sequences in the Drosophila mod(mdg4) intron promote poly(A)-independent transcription termination and trans-splicing.Nucleic acids research · 2018Article
- The evolutionary landscape of intergenic trans-splicing events in insects.Nature communications · 2015Article
- Genome-wide survey of Alternative Splicing in Sorghum Bicolor.Physiology and molecular biology of plants : an international journal of functional plant biology · 2014Article
- Replacement of huntingtin exon 1 by trans-splicing.Cellular and molecular life sciences : CMLS · 2012Article
- Drosophila CTCF tandemly aligns with other insulator proteins at the borders of H3K27me3 domains.Genome research · 2012Article
- Chromatin insulators: a role in nuclear organization and gene expression.Advances in cancer research · 2011Review
- Alternative splicing and evolution: diversification, exon definition and function.Nature reviews. Genetics · 2010Review
- Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3.BMC genetics · 2009Article
- Coordinated control of dCTCF and gypsy chromatin insulators in Drosophila.Molecular cell · 2007Article
- Role of the mod(mdg4) common region in homolog segregation in Drosophila male meiosis.Genetics · 2007Article
- Article
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2 authors.
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Abstract
The relative position of exons in genes can be altered only after large structural mutations. These mutations are frequently deleterious, impairing transcription, splicing, RNA stability, or protein function, as well as imposing strong inflexibility to protein evolution. Alternative cis- or trans-splicing may overcome the need for genomic structural stability, allowing genes to encode new proteins without the need to maintain a specific exon order. Trans-splicing in the Drosophila melanogaster modifier of mdg4 (mod[mdg4]) gene is the best documented example in which this process plays a major role in the maturation of mRNAs. Comparison of the genomic organization of this locus among several insect species suggests that the divergence between the lineages of the mosquito Anopheles gambiae and D. melanogaster involved an extensive exon rearrangement, requiring >11 breakpoints within the mod(mdg4) gene. The massive reorganization of the locus also included the deletion or addition of a new function as well as exon duplications. Whereas both DNA strands are sense strands in the Drosophila gene, the coding region in mosquito lays in a single strand, suggesting that trans-splicing may have originated in the Drosophila lineage and might have been the triggering factor for such a dramatic reorganization.
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