Evidence map›Paper›PMID 14525873›Full record

ArticleBMJ (Clinical research ed.)2003

Dietary fat intake and risk of stroke in male US healthcare professionals: 14 year prospective cohort study.

Ka He, Anwar Merchant, Eric B Rimm, Bernard A Rosner, Meir J Stampfer, Walter C Willett, Alberto Ascherio

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005182 (Health Professionals Follow-up Study), which is not on this map. Cited by 63 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 20 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005182 completednot on this map

Health Professionals Follow-up Study

TypeobservationalSponsorHarvard School of Public Health (HSPH)Ran1985 to 2008Enrolled50,000ConditionsCardiovascular Diseases, Cerebrovascular Accident, Coronary Disease, Peripheral Vascular Diseases
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 20 syntheses or guidelines pooled it, 196 citations in OpenAlex.

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  10. Can dietary saturated fat be beneficial in prevention of stroke risk? A meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016
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  13. Nut consumption and risk of stroke.European journal of epidemiology · 2015
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ka HeDepartment of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. hpkhe@channing.harvard.edu
Anwar Merchant
Eric B Rimm
Bernard A Rosner
Meir J Stampfer
Walter C Willett
Alberto Ascherio
Harvard University · US

Funding

Dietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6M
NCI NIH HHS CA55075NHLBI NIH HHS HL35464
6 · The paper itself

Abstract

objectiveTo examine the association between intake of total fat, specific types of fat, and cholesterol and risk of stroke in men. Design and setting Health professional follow up study with 14 year follow up.

participants43 732 men aged 40-75 years who were free from cardiovascular diseases and diabetes in 1986.

main outcome measureRelative risk of ischaemic and haemorrhagic stroke according to intake of total fat, cholesterol, and specific types of fat.

resultsDuring the 14 year follow up 725 cases of stroke occurred, including 455 ischaemic strokes, 125 haemorrhagic stokes, and 145 strokes of unknown type. After adjustment for age, smoking, and other potential confounders, no evidence was found that the amount or type of dietary fat affects the risk of developing ischaemic or haemorrhagic stroke. Comparing the highest fifth of intake with the lowest fifth, the multivariate relative risk of ischaemic stroke was 0.91 (95% confidence interval 0.65 to 1.28; P for trend = 0.77) for total fat, 1.20 (0.84 to 1.70; P = 0.47) for animal fat, 1.07 (0.77 to 1.47; P = 0.66) for vegetable fat, 1.16 (0.81 to 1.65; P = 0.59) for saturated fat, 0.91 (0.65 to 1.28; P = 0.83) for monounsaturated fat, 0.88 (0.64 to 1.21; P = 0.25) for polyunsaturated fat, 0.87 (0.62 to 1.22; P = 0.42) for trans unsaturated fat, and 1.02 (0.75 to 1.39; P = 0.99) for dietary cholesterol. Intakes of red meats, high fat dairy products, nuts, and eggs were also not appreciably related to risk of stroke.

conclusionsThese findings do not support associations between intake of total fat, cholesterol, or specific types of fat and risk of stroke in men.

Indexed as

AdultAgedCohort StudiesDietary FatsEnergy IntakeFollow-Up StudiesHealth PersonnelHumansMaleMiddle AgedMultivariate AnalysisProportional Hazards ModelsProspective StudiesRisk FactorsStrokeUnited StatesDietary Fats

Identifiers

PMID14525873
PMCPMC214078
OpenAlexW2151373895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.