ReviewEuropean journal of pediatrics2003
The role of bisphosphonates in diseases of childhood.
Review in European journal of pediatrics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Systematic review of effectiveness of bisphosphonates in treatment of low bone mineral density and fragility fractures in juvenile idiopathic arthritis.Archives of disease in childhood · 2006Pooled it
- Short-term efficacy of monthly pamidronate infusion in patients with osteogenesis imperfecta.Journal of Korean medical science · 2007Trial
- Pamidronate distribution in pediatric renal and rheumatologic patients.European journal of clinical pharmacology · 2006Trial
- Effect of bisphosphonates on the crystallization of stone-forming salts in synthetic urine.Investigative and clinical urology · 2020Article
- Efficacy of pamidronate in pediatric osteosarcoma patients with low bone mineral density.Annals of pediatric endocrinology & metabolism · 2016Article
- Effect of alendronate on the mandible and long bones: an experimental study in vivo.Pediatric research · 2015Article
- Oral Alendronate Treatment for Severe Polyostotic Fibrous Dysplasia due to McCune-Albright Syndrome in a Child: A Case Report.International journal of pediatric endocrinology · 2010Article
- Reversal of hypercalcemic acute kidney injury by treatment with intravenous bisphosphonates.Pediatric nephrology (Berlin, Germany) · 2009Article
- Efficacy of intravenous alendronate for the treatment of glucocorticoid-induced osteoporosis in children with autoimmune diseases.Clinical rheumatology · 2008Article
- Alendronate treatment promotes bone formation with a less anisotropic microstructure during intramembranous ossification in rats.Journal of bone and mineral metabolism · 2008Article
- [Diagnosis, prophylaxis and therapy of osteoporosis in juvenile idiopathic arthritis: consensus statement of the German Association for Pediatric Rheumatology].Zeitschrift fur Rheumatologie · 2007Article
- Osteoporosis in juvenile idiopathic arthritis--a practical approach to diagnosis and therapy.European journal of pediatrics · 2007Review
- Sustained beneficial effect of intravenous bisphosphonates after their discontinuation in children.Pediatric nephrology (Berlin, Germany) · 2007Article
- Idiopathic infantile arterial calcification: clinical presentation, therapy and long-term follow-up.European journal of pediatrics · 2006Article
- Vitamin D intoxication and therapy with alendronate (case report and review of literature).European journal of pediatrics · 2006Review
- Neonatal severe hyperparathyroidism: genotype/phenotype correlation and the use of pamidronate as rescue therapy.European journal of pediatrics · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bisphosphonates are synthetic analogues of pyrophosphate that inhibit bone resorption by their action on osteoclasts. In recent years, bisphosphonates have been used in children for treatment of a growing number of disorders associated primarily with generalized or localized osteoporosis, metabolic bone diseases, heterotopic calcification in soft tissues, and for resistant hypercalcemia. In the present review we discuss the pharmacological aspects of bisphosphonates and related bone pathophysiology, review the pediatric literature on the role of bisphosphonates in childhood diseases and our experience with these drugs. The theoretical concerns of possible adverse effects of these drugs on the growing skeleton have not materialized in the limited pediatric clinical experience. Bisphosphonates provide the pediatrician with an opportunity to treat mineral and bone disorders of childhood which until recently did not have satisfactory therapy, at the same time, being aware of the theoretical concerns on microdamage accumulation in bone, bone quality and teratogenic potential of these drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.