ArticleLeukemia2003
Segmental chromosomal aberrations and centrosome amplifications: pathogenetic mechanisms in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma?
Article in Leukemia, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- CD30 induces Reed-Sternberg cell-like morphology and chromosomal instability in classic Hodgkin lymphoma cell lines.Cancer science · 2023Article
- Genetic lesions and targeted therapy in Hodgkin lymphoma.Therapeutic advances in hematology · 2023Review
- Centrosome Defects in Hematological Malignancies: Molecular Mechanisms and Therapeutic Insights.Blood science (Baltimore, Md.) · 2022Review
- Differences in nuclear DNA organization between lymphocytes, Hodgkin and Reed-Sternberg cells revealed by structured illumination microscopy.Journal of cellular biochemistry · 2014Article
- Aurora B kinase in Hodgkin lymphoma: immunohistochemical pattern of expression in neoplastic Hodgkin and Reed-Sternberg cells.Journal of molecular histology · 2014Article
- The kelch protein KLHDC8B guards against mitotic errors, centrosomal amplification, and chromosomal instability.The Journal of biological chemistry · 2012Article
- The c-Rel Transcription Factor in Development and Disease.Genes & cancer · 2011Article
- The homologous recombination protein RAD51D mediates the processing of 6-thioguanine lesions downstream of mismatch repair.Molecular cancer research : MCR · 2011Article
- RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.The EMBO journal · 2011Article
- A clinical overview of centrosome amplification in human cancers.International journal of biological sciences · 2011Review
- Dynamic chromosomal rearrangements in Hodgkin's lymphoma are due to ongoing three-dimensional nuclear remodeling and breakage-bridge-fusion cycles.Haematologica · 2010Article
- Conflicting results of prenatal FISH with different probes for Down's Syndrome critical regions associated with mosaicism for a de novo del(21)(q22) characterised by molecular karyotyping: Case report.Molecular cytogenetics · 2010Article
- Mutations in a gene encoding a midbody protein in binucleated Reed-Sternberg cells of Hodgkin lymphoma.Cell cycle (Georgetown, Tex.) · 2010Article
- Hodgkin lymphoma: an update on its biology with new insights into classification.Clinical lymphoma & myeloma · 2009Review
- The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed-Sternberg cells.Leukemia · 2009Article
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- Article
- Review
- Genomic alterations in Hodgkin's lymphoma.International journal of hematology · 2006Review
- Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells.Oncogene · 2005Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor cell metaphases of classical Hodgkin's lymphoma (cHL) characteristically display highly rearranged karyotypes with chromosome numbers in the hyperploid range and marked intraclonal variability. The causes of this cytogenetic pattern remain largely unknown. An unusual type of chromosomal abnormality coined as segmental chromosomal aberration (SCA) has been recurrently observed in HL cell lines and was suggested to be associated with ribosomal DNA (rDNA) rearrangements. Moreover, centrosome abnormalities provoking deficient chromosome segregation have been reported in many solid tumors and also in cHL cell lines. Whether SCA, rDNA rearrangements or centrosome abnormalities also occur in primary cHL is not yet known. Thus, we performed extensive molecular cytogenetic and immunohistological studies in two cHL cases. Both cases presented SCA associated with genomic gains of the REL and JAK2 loci, respectively. The SCA involving JAK2 was associated with rDNA rearrangements. The absolute centrosome size of HRS cells in both cases was significantly larger than in non-HRS cells, but the relative centrosome size of HRS cells corrected for nuclear size was in the same range as that of the non-neoplastic cells. These findings demonstrate that the various mechanisms associated with chromosomal instability warrant a more detailed characterization in cHL.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.