ArticleProceedings of the National Academy of Sciences of the United States of America2003
Positive selection on protein-length in the evolution of a primate sperm ion channel.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 88 citations in OpenAlex.
- Intrinsically disordered proteins: Ensembles at the limits of Anfinsen's dogma.Biophysics reviews · 2022Review
- Unconventional conservation reveals structure-function relationships in the synaptonemal complex.eLife · 2021Article
- Article
- Spontaneous Switching among Conformational Ensembles in Intrinsically Disordered Proteins.Biomolecules · 2019Review
- Comparative genomic analysis suggests that the sperm-specific sodium/proton exchanger and soluble adenylyl cyclase are key regulators of CatSper among the Metazoa.Zoological letters · 2019Article
- Parallel Evolution of Sperm Hyper-Activation Ca2+ Channels.Genome biology and evolution · 2017Article
- Structural evolution of CatSper1 in rodents is influenced by sperm competition, with effects on sperm swimming velocity.BMC evolutionary biology · 2014Article
- Article
- Evolution of protein indels in plants, animals and fungi.BMC evolutionary biology · 2013Article
- Sea star populations diverge by positive selection at a sperm-egg compatibility locus.Ecology and evolution · 2013Article
- The case for intrinsically disordered proteins playing contributory roles in molecular recognition without a stable 3D structure.F1000 biology reports · 2013Article
- An indel polymorphism in the hybrid incompatibility gene lethal hybrid rescue of Drosophila is functionally relevant.Genetics · 2012Article
- Article
- Tropomyosin is a nice marker gene for phylogenetic analysis of molluscs.Molecular biology reports · 2011Article
- Extraordinary sequence divergence at Tsga8, an X-linked gene involved in mouse spermiogenesis.Molecular biology and evolution · 2011Article
- Pseudogenization of the umami taste receptor gene Tas1r1 in the giant panda coincided with its dietary switch to bamboo.Molecular biology and evolution · 2010Article
- Evolution of the sweet taste receptor gene Tas1r2 in bats.Molecular biology and evolution · 2010Article
- Understanding protein non-folding.Biochimica et biophysica acta · 2010Review
- A zinc-binding site by negative selection induces metallodrug susceptibility in an essential chaperonin.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Positive selection neighboring functionally essential sites and disease-implicated regions of mammalian reproductive proteins.BMC evolutionary biology · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Positive Darwinian selection on advantageous point substitutions has been demonstrated in many genes. We here provide empirical evidence, for the first time, that positive selection can also act on insertion/deletion (indel) substitutions in the evolution of a protein. CATSPER1 is a voltage-gated calcium channel found exclusively in the plasma membrane of the mammalian sperm tail and it is essential for sperm motility. We determined the DNA sequences of the first exon of the CATSPER1 gene from 15 primates, which encodes the intracellular N terminus region of approximately equal to 400 aa. These sequences exhibit an excessively high frequency of indels. However, all indels have lengths that are multiples of 3 nt (3n indels) and do not disrupt the ORF. The number of indel substitutions per site per year in CATSPER1 is five to eight times the corresponding rates calculated from two large-scale primate genomic comparisons, which represent the neutral rate of indel substitutions. Moreover, CATSPER1 indels are considerably longer than neutral indels. These observations strongly suggest that positive selection has been promoting the fixation of indel mutations in CATSPER1 exon 1. It has been shown in certain ion channels that the length of the N terminus region affects the rate of channel inactivation. This finding suggests that the selection detected may be related to the regulation of the CATSPER1 channel, which can affect sperm motility, an important determinant in sperm competition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.