ArticleGenes & development2003
mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells.
Article in Genes & development, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 91 citations in OpenAlex.
- BAHCC1 promotes gene expression in neuronal cells by antagonizing SIN3A-HDAC1.Nucleic acids research · 2025Article
- Divergent destinies: insights into the molecular mechanisms underlying EPI and PE fate determination.Life science alliance · 2025Review
- Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex.Nature communications · 2023Article
- Sin3a regulates the developmental progression through morula-to-blastocyst transitionFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Inositol phosphates and core subunits of the Sin3L/Rpd3L histone deacetylase (HDAC) complex up-regulate deacetylase activity.The Journal of biological chemistry · 2019Article
- In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression.Journal of visualized experiments : JoVE · 2019Article
- Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex.The Biochemical journal · 2018Review
- Zebrafish sin3b mutants are viable but have size, skeletal, and locomotor defects.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer.Oncotarget · 2016Article
- Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Stress-mediated Sin3B activation leads to negative regulation of subset of p53 target genes.Bioscience reports · 2015Article
- Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Transcriptional co-repressors and memory storage.Neuropharmacology · 2014Review
- Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice.Blood · 2013Article
- Foxk1 recruits the Sds3 complex and represses gene expression in myogenic progenitors.The Biochemical journal · 2012Article
- Chromatin associated Sin3A is essential for male germ cell lineage in the mouse.Developmental biology · 2012Article
- Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability.Oncogene · 2012Article
- HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells.Cell death and differentiation · 2012Article
- Association of the interferon-β gene with pericentromeric heterochromatin is dynamically regulated during virus infection through a YY1-dependent mechanism.Nucleic acids research · 2012Article
- Epigenetic mechanisms and genome stability.Clinical epigenetics · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The histone code guides many aspects of chromosome biology including the equal distribution of chromosomes during cell division. In the chromatin domains surrounding the centromere, known as pericentric heterochromatin, histone modifications, particularly deacetylation and methylation, appear to be essential for proper chromosome segregation. However, the specific factors and their precise roles in this highly orchestrated process remain under active investigation. Here, we report that germ-line or somatic deletion of mSds3, an essential component of the functional mSin3/HDAC corepressor complex, generates a cell-lethal condition associated with rampant aneuploidy, defective karyokinesis, and consequently, a failure of cytokinesis. mSds3-deficient cells fail to deacetylate and methylate pericentric heterochromatin histones and to recruit essential heterochromatin-associated proteins, resulting in aberrant associations among heterologous chromosomes via centromeric regions and consequent failure to properly segregate chromosomes. Mutant mSds3 molecules that are defective in mSin3 binding fail to rescue the mSds3 null phenotypes. On the basis of these findings, we propose that mSds3 and its associated mSin3/HDAC components play a central role in initiating the cascade of pericentric heterochromatin-specific modifications necessary for the proper distribution of chromosomes during cell division in mammalian cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.