ReviewCell proliferation2003
Epithelial progenitor cell lines as models of normal breast morphogenesis and neoplasia.
Review in Cell proliferation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Of mice and women: a comparative tissue biology perspective of breast stem cells and differentiation.Journal of mammary gland biology and neoplasia · 2015Review
- Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Hormone-responsive 3D multicellular culture model of human breast tissue.Biomaterials · 2012Article
- Statistical association of basal cell keratins with metastasis-inducing proteins in a prognostically unfavorable group of sporadic breast cancers.The American journal of pathology · 2011Article
- MUC1-positive circulating tumor cells and MUC1 protein predict chemotherapeutic efficacy in the treatment of metastatic breast cancer.Chinese journal of cancer · 2011Article
- Development and characterization of a new marine fish cell line from turbot (Scophthalmus maximus).Fish physiology and biochemistry · 2010Article
- Full-length cytokeratin-19 is released by human tumor cells: a potential role in metastatic progression of breast cancer.Breast cancer research : BCR · 2009Article
- Article
- Prostate cell cultures as in vitro models for the study of normal stem cells and cancer stem cells.Prostate cancer and prostatic diseases · 2008Review
- Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells.Breast cancer research : BCR · 2008Article
- PMC42, a breast progenitor cancer cell line, has normal-like mRNA and microRNA transcriptomes.Breast cancer research : BCR · 2008Article
- Localization of putative stem cells and four cell populations with different differentiation degree in mouse mammary anlagen.Histochemistry and cell biology · 2006Article
- Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status.The American journal of pathology · 2006Article
- Article
- Intrauterine breast development and the mammary myoepithelial lineage.Journal of mammary gland biology and neoplasia · 2005Review
- Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia.Journal of mammary gland biology and neoplasia · 2005Review
- The protective role of pregnancy in breast cancer.Breast cancer research : BCR · 2005Review
- Maintenance of cell type diversification in the human breast.Journal of mammary gland biology and neoplasia · 2005Review
- Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer.Breast cancer research : BCR · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
The majority of human breast carcinomas exhibit luminal characteristics and as such, are most probably derived from progenitor cells within the luminal epithelial compartment. This has been subdivided recently into at least three luminal subtypes based on gene expression patterns. The value of knowing the cellular origin of individual tumours is clear and should aid in designing effective therapies. To do this, however, we need strategies aimed at defining the nature of stem and progenitor cell populations in the normal breast. In this review, we will discuss our technical approach for delineating the origin of the epithelial cell types. A major step forward was the purification of each cell type by the application of immunomagnetic cell sorting based on expression of lineage-specific surface antigens. We then developed chemically defined media that could support either the luminal epithelial or the myoepithelial cell phenotype in primary cultures. Having succeeded in continuous propagation presumably without loss of markers, we could show that a subset of the luminal epithelial cells could convert to myoepithelial cells, signifying the possible existence of a progenitor cell population. By combining the information on marker expression and in situ localization with immunomagnetic sorting and subsequent immortalization, we have identified and isolated a cytokeratin 19-positive suprabasal putative precursor cell in the luminal epithelial compartment and established representative cell lines. This suprabasal-derived epithelial cell line is able to generate both itself and differentiated luminal epithelial and myoepithelial cells, and in addition, is able to form elaborate terminal duct lobular unit (TDLU)-like structures within a reconstituted basement membrane. As more than 90% of breast cancers arise in TDLUs and more than 90% are also cytokeratin 19-positive, we suggest that this cell population contains a breast-cancer progenitor.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.