ReviewCell proliferation2003
Mammary epithelial stem cells: transplantation and self-renewal analysis.
Review in Cell proliferation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Functional Gene Expression Differentiation of the Notch Signaling Pathway in Female Reproductive Tract Tissues-A Comprehensive Review With Analysis.Frontiers in cell and developmental biology · 2020Pooled it
- Establishment of a sheep immortalization cell line for generating and amplifying Orf virus recombinants.Frontiers in veterinary science · 2022Article
- Contribution of an alveolar cell of origin to the high-grade malignant phenotype of pregnancy-associated breast cancer.Oncogene · 2014Article
- Article
- Expression of Notch receptors, ligands, and target genes during development of the mouse mammary gland.Journal of cellular physiology · 2011Article
- Article
- Prolactin regulation of mammary gland development.Journal of mammary gland biology and neoplasia · 2008Review
- Wnt signaling, stem cells, and the cellular origin of breast cancer.Stem cell reviews · 2007Review
- Localization of putative stem cells and four cell populations with different differentiation degree in mouse mammary anlagen.Histochemistry and cell biology · 2006Article
- The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium.Breast cancer research : BCR · 2006Review
- Stem/progenitor cells in mouse mammary gland development and breast cancer.Journal of mammary gland biology and neoplasia · 2005Review
- Stem cells and tissue homeostasis in mammary glands.Journal of mammary gland biology and neoplasia · 2005Article
- Stem cells and mammary cancer in mice.Stem cell reviews · 2005Review
- Stem cells in mammary development and carcinogenesis: implications for prevention and treatment.Stem cell reviews · 2005Review
- Self-renewal and solid tumor stem cells.Oncogene · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
An entire mammary epithelial outgrowth, capable of full secretory differentiation, may be comprised of the progeny of a single cellular antecedent. This conclusion is based upon the maintenance of retroviral insertion sites within the somatic DNA of successive transplant generations derived from a single mammary fragment. In addition, dissociation of these clonal dominant glands and implantation of dispersed cells at limiting dilution demonstrated that both duct-limited and lobule-limited outgrowths were developed, as well as complete, fully differentiated glands. Thus, transplantation has revealed three distinct mammary epithelial progenitors in the mouse. Similar studies have extended this observation to rat mammary tissue. Recently, using cre-lox conditional activation of reporter genes, a new epithelial progenitor, specific for mammary secretory epithelium in postlactation females has been uncovered. In situ, these cells were shown to regenerate secretory lobules upon successive pregnancies. In transplant studies, they demonstrated the capacity for self-renewal and contributed to the new generation of all of the known epithelial cell types among mammary epithelium. In limiting dilution, the parity-induced progenitors were capable of engendering lobule-limited and duct-limited outgrowths in their entirety, but not completely developed glands. Serial transplant studies indicate that these progenitors have a significant but limited capacity for self-renewal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.